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Evidence-Based Complementary and Alternative MedicineVolume 2013 2013, Article ID 157635, 7 pages

Research Article

Natural Products Research Center and Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai 90112, Thailand

Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai 90112, Thailand

Received 25 January 2013; Accepted 23 April 2013

Academic Editor: Shu-Ming Wang

Copyright © 2013 Julalak Chorachoo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Rhodomyrtone isolated from the leaves of Rhodomyrtus tomentosa possesses antibacterial, anti-inflammatory, and anti-oxidant activities. Since rhodomyrtone is insoluble in water, it is rather difficult to get to the target sites in human body. Liposome exhibited ability to entrap both hydrophilic and hydrophobic compounds and easily penetrate to the target site. The present study aimed to develop a novel liposomal encapsulated rhodomyrtone formulations. In addition, characterization of liposome, stability profiles, and their antiacne activity were performed. Three different formulations of total lipid concentrations 60, 80, and 100 μmol-mL were used. Formulation with 60 μmol-mL total lipid phosphatidylcholine from soybean and cholesterol from lanolin in 4 : 1, w-w exhibited the highest rhodomyrtone encapsulation efficacy 65.47 ± 1.7%, average particle size 209.56 ± 4.8 nm, and ζ-potential –41.19 ± 1.3 mV. All formulations demonstrated good stability when stored for 2 months in dark at 4°C as well as room temperature. Minimal inhibitory concentration and minimal bactericidal concentration values of liposomal formulation against 11 clinical bacterial isolates and reference strains ranged from 1 to 4 and from 4 to 64 μg-mL, respectively, while those of rhodomyrtone were 0.25–1 and 0.5–2 μg-mL, respectively. The MIC and MBC values of liposome formulation were more effective than topical drugs against Staphylococcus aureus and Staphylococcus epidermidis.

Autor: Julalak Chorachoo, Thanaporn Amnuaikit, and Supayang P. Voravuthikunchai



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