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European Journal of Medical Research

, 21:25

First Online: 16 June 2016Received: 16 February 2016Accepted: 03 June 2016DOI: 10.1186-s40001-016-0220-2

Cite this article as: Fu, C., Shi, Y. & Yao, Z. Eur J Med Res 2016 21: 25. doi:10.1186-s40001-016-0220-2


Background and aimsMHC class I polypeptide-related chain A MICA molecule is induced in response to viral infection, various types of stress, such as endoplasmic reticulum stress, and ischemia or-and reperfusion, by which MICA was shed from the cell surface into the extracellular domain, generating a soluble form sMICA. In the present study, we designed to investigate the serum sMICA level in patients with AMI and determine whether sMICA could be an early biomarker for diagnosis of AMI.

MethodsThere were 103 patients who presented with first-time AMI that was assessed after the incident. The control group consisted of 103 healthy volunteers. Serum levels of sMICA and Troponin T were detected by the specific ELISA kits.

ResultsSerum levels of sMICA reach the peaks 1.34 ± .18 and 1.72 ± .20n-l at 6–12 h and serum levels of cTnT reach the peaks 1.16 ± .28 and 1.14 ± .34n-l at 12–24 h. Both of them were significantly higher than the healthy controls .168 ± .014 n-l, p = .000 for sMICA and .13 ± .06 n-l, p = .000 for Troponin T cTnT. sMICA is more sensitive in the early diagnosis of AMI than cTnT. The combined ROC analysis revealed an AUC value of .78 95 % CI .69–.83 in discriminating AMI patients from healthy controls.

ConclusionsWe have detected high levels of sMICA in patients with AMI. Elevated serum sMICA may be a novel biomarker for the early detection of myocardial injury in humans.

KeywordsAcute myocardial infarction MHC class I polypeptide-related chain A Troponin T  Download fulltext PDF

Autor: Cunyu Fu - Yunxiang Shi - Zongqin Yao


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