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Histochemistry and Cell Biology

, 130:481

First Online: 22 July 2008Accepted: 12 June 2008DOI: 10.1007-s00418-008-0464-1

Cite this article as: De Wever, O., Pauwels, P., De Craene, B. et al. Histochem Cell Biol 2008 130: 481. doi:10.1007-s00418-008-0464-1

Abstract

Reduction of epithelial cell–cell adhesion via the transcriptional repression of cadherins in combination with the acquisition of mesenchymal properties are key determinants of epithelial–mesenchymal transition EMT. EMT is associated with early stages of carcinogenesis, cancer invasion and recurrence. Furthermore, the tumor stroma dictates EMT through intensive bidirectional communication. The pathological analysis of EMT signatures is critically, especially to determine the presence of cancer cells at the resection margins of a tumor. When diffusion barriers disappear, EMT markers may be detected in sera from cancer patients. The detection of EMT signatures is not only important for diagnosis but can also be exploited to enhance classical chemotherapy treatments. In conclusion, further detailed understanding of the contextual cues and molecular mediators that control EMT will be required in order to develop diagnostic tools and small molecule inhibitors with potential clinical implications.

KeywordsStroma Cadherin EMT Metastasis Therapy  Download fulltext PDF



Autor: Olivier De Wever - Patrick Pauwels - Bram De Craene - Michèle Sabbah - Shahin Emami - Gérard Redeuilh - Christian Gespa

Fuente: https://link.springer.com/







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