Clinical and surgical risk factors in the development of proliferative vitreoretinopathy following retinal detachment surgery: a systematic review protocolReportar como inadecuado

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Systematic Reviews

, 5:107

First Online: 08 July 2016Received: 08 April 2016Accepted: 08 June 2016DOI: 10.1186-s13643-016-0284-7

Cite this article as: Chaudhary, R., Dretzke, J., Scott, R. et al. Syst Rev 2016 5: 107. doi:10.1186-s13643-016-0284-7


BackgroundProliferative vitreoretinopathy PVR is a known complication of retinal detachment surgery. It has been postulated that the establishment of PVR involves inflammatory and ischaemic processes. Surgical and clinical risk factors contribute to making certain patients more vulnerable to developing PVR.

The objective of this systematic review is to identify and appraise the evidence on clinical and surgical risk factors and their utility in predicting the occurrence or worsening of PVR post-surgery.

MethodsElectronic databases and grey literature will be searched dating from 1980. Studies will be eligible if they include patients that underwent retinal reattachment surgery for rhegmatogenous retinal detachment RRD, with and without PVR, and where risk factors were measured before or during surgery. Screening, data extraction and quality assessment will be performed independently by two reviewers using pre-defined criteria. Should any models be identified, we will liaise with the Cochrane prognostic group to help define the most appropriate quality assessment criteria based on the PROBLAST tool which is in development. All findings will be tabulated and narratively synthesised. Studies presenting models or adjusted data will likely be more informative than studies reporting unadjusted results for a single risk factor. When clinically and methodologically appropriate, random effects meta-analysis will be performed.

DiscussionThis review will systematically and comprehensively retrieve evidence to evaluate the clinical and surgical risk factors associated with PVR. The identified evidence may aid standardisation of clinical practice and more effective management for improving patient outcomes following RRD surgery and will provide a clear reference point for vitreoretinal surgeons.

Systematic review registrationPROSPERO CRD42016035848

KeywordsProliferative vitreoretinopathy Retinal detachment Clinical risk factors Surgical risk factors Electronic supplementary materialThe online version of this article doi:10.1186-s13643-016-0284-7 contains supplementary material, which is available to authorized users.

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Autor: Rishika Chaudhary - Janine Dretzke - Robert Scott - Ann Logan - Richard Blanch


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