Prognostic implications of PD-L1 expression in patients with soft tissue sarcomaReportar como inadecuado




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BMC Cancer

, 16:434

Translational oncology

Abstract

BackgroundThe PD-1-PD-L1 axis plays a paramount role in the immune escape of tumor cells by negative regulation of T-cell functions. The aim of the present study was to characterize the PD-L1 expression pattern and its clinical implication in soft-tissue sarcomas STS.

MethodsWe analyzed PD-L1 expression in 82 STS patients with 5 subtypes: rhabdomyosarcoma, synovial sarcoma, Ewing sarcoma, epithelioid sarcoma, and mesenchymal chondrosarcoma.

ResultsThe median age at diagnosis was 26 range: 1–78 and the male to female ratio was 1.6. The majority 80 % of patients showed locoregional disease rather than metastatic disease at diagnosis. Thirty-five cases 43 % showed PD-L1 expression and the proportion of PD-L1 expression was significantly different according to histologic subtypes P = 0.004; highest in epithelioid sarcoma 100 %, 7-7, followed by synovial sarcoma 53 %, 10-19, rhabdomyosarcoma 38 %, 12-32, and Ewing sarcoma 33 %, 6-18, while it was not expressed in mesenchymal chondrosarcoma 0 %, 0-6. STS patients with PD-L1 expression had worse overall survival compared with those without PD-L1 expression 5-year survival rate: 48 % vs. 68 %, P = 0.015. The Cox proportional hazard model adjusted for histologic subtype, initial metastasis, and PD-L1 expression showed that PD-L1 expression was significantly associated with shorter overall survival P = 0.037, HR 2.57, 95 % CI 1.060–6.231.

ConclusionWe have confirmed PD-L1 expression in various STS of young population and demonstrated its independent negative prognostic role, thereby suggesting the PD-1-PD-L1 axis as a potential therapeutic target for the treatment of young STS patients.

KeywordsSoft tissue sarcoma PD-L1 Biomarker Prognosis Electronic supplementary materialThe online version of this article doi:10.1186-s12885-016-2451-6 contains supplementary material, which is available to authorized users.

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Autor: Chan Kim - Eun Kyung Kim - Hun Jung - Hong Jae Chon - Jung Woo Han - Kyoo-Ho Shin - Hyuk Hu - Kyung Sik Kim - Young D

Fuente: https://link.springer.com/







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