Rethinking the assessment of risk of bias due to selective reporting: a cross-sectional studyReportar como inadecuado

Rethinking the assessment of risk of bias due to selective reporting: a cross-sectional study - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Systematic Reviews

, 5:108

First Online: 08 July 2016Received: 24 March 2016Accepted: 20 June 2016DOI: 10.1186-s13643-016-0289-2

Cite this article as: Page, M.J. & Higgins, J.P.T. Syst Rev 2016 5: 108. doi:10.1186-s13643-016-0289-2


BackgroundSelective reporting is included as a core domain of Cochrane’s tool for assessing risk of bias in randomised trials. There has been no evaluation of review authors’ use of this domain. We aimed to evaluate assessments of selective reporting in a cross-section of Cochrane reviews and to outline areas for improvement.

MethodsWe obtained data on selective reporting judgements for 8434 studies included in 586 Cochrane reviews published from issue 1–8, 2015. One author classified the reasons for judgements of high risk of selective reporting bias. We randomly selected 100 reviews with at least one trial rated at high risk of outcome non-reporting bias non-partial reporting of an outcome on the basis of its results. One author recorded whether the authors of these reviews incorporated the selective reporting assessment when interpreting results.

ResultsOf the 8434 studies, 1055 13 % were rated at high risk of bias on the selective reporting domain. The most common reason was concern about outcome non-reporting bias. Few studies were rated at high risk because of concerns about bias in selection of the reported result e.g. reporting of only a subset of measurements, analysis methods or subsets of the data that were pre-specified. Review authors often specified in the risk of bias tables the study outcomes that were not reported 84 % of studies but less frequently specified the outcomes that were partially reported 61 % of studies. At least one study was rated at high risk of outcome non-reporting bias in 31 % of reviews. In the random sample of these reviews, only 30 % incorporated this information when interpreting results, by acknowledging that the synthesis of an outcome was missing data that were not-partially reported.

ConclusionsOur audit of user practice in Cochrane reviews suggests that the assessment of selective reporting in the current risk of bias tool does not work well. It is not always clear which outcomes were selectively reported or what the corresponding risk of bias is in the synthesis with missing outcome data. New tools that will make it easier for reviewers to convey this information are being developed.

KeywordsBias Quality Methodology Randomised trials Systematic reviews Electronic supplementary materialThe online version of this article doi:10.1186-s13643-016-0289-2 contains supplementary material, which is available to authorized users.

Download fulltext PDF

Autor: Matthew J. Page - Julian P. T. Higgins


Documentos relacionados