The prognostic role of systemic inflammatory markers on HIV-infected patients with non-Hodgkin lymphoma, a multicenter cohort studyReportar como inadecuado

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Journal of Translational Medicine

, 13:89

First Online: 14 March 2015Received: 06 December 2014Accepted: 24 February 2015DOI: 10.1186-s12967-015-0446-8

Cite this article as: Raffetti, E., Donato, F., Castelnuovo, F. et al. J Transl Med 2015 13: 89. doi:10.1186-s12967-015-0446-8


BackgroundThe systemic inflammatory response has been postulated as having prognostic significance in a wide range of different cancer types. We aimed to assess the prognostic role of inflammatory markers on survival in HIV-infected patients with Non-Hodgkin Lymphoma NHL, and to compute a prognostic score based on inflammatory biomarkers.

MethodsWe evaluated data on HIV patients with NLH diagnosis between 1998 and 2012 in a HIV Italian Cohort. Using Cox proportional regression model, we assessed the prognostic role of Neutrophil-Lymphocyte Ratio NLR, Platelet-Lymphocyte Ratio PLR, Glasgow Prognostic Score GPS, modified Glasgow Prognostic Score mGPS, Prognostic Index PI, and Prognostic Nutritional Index PNI. We also computed a risk score equation, assigning patients to a derivation and a validation sample. The area under the curve AUC was use to evaluate the predictive ability of this score.

Results215 non-Hodgkin lymphoma cases 80.0% males with a mean age of 43.2 years were included. Deaths were observed in 98 45.6% patients during a median follow up of 5 years. GPS, mGPS, PI and PNI were independently associated with risk of death. We also computed a mortality risk score which included PNI and occurrence of an AIDS event within six months from NHL diagnosis. The AUCs were 0.69 95% CI 0.58 to 0.81 and 0.69 95% CI 0.57 to 0.81 at 3 and 5 years of the follow-up, respectively.

ConclusionsGPS, mGPS, PI and PNI are independent prognostic factors for survival of HIV patients with NHL.

KeywordsInflammatory markers Prognostic score HIV Non-Hodgkin lymphoma AbbreviationsNHLNon-hodgkin lymphoma

cARTCombined antiretroviral therapy

IPIInternational prognostic index

LDHLactate dehydrogenase

CRPC-reactive protein

GPSGlasgow prognostic score

NLRNeutrophil-lymphocyte ratio

PLRPlatelet-lymphocyte ratio

HBVHepatitis B virus; HCV: Hepatitis C virus

HCVViral hepatitis C

mGPSModified glasgow prognostic score

PIPrognostic index

PNIPrognostic nutritional index

HRHazards ratio

95% CI95% confidence interval

ROCReceiver operating characteristic

AUCArea under the receiver operating characteristic curve

SDStandard deviation

RmRisk of mortality

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Autor: Elena Raffetti - Francesco Donato - Filippo Castelnuovo - Nicoletta Ladisa - Giuseppe Paraninfo - Elisa Di Filippo - Daniela


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