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Histochemistry and Cell Biology

, Volume 129, Issue 5, pp 563–578

First Online: 21 February 2008Accepted: 06 February 2008DOI: 10.1007-s00418-008-0401-3

Cite this article as: Roepstorff, K., Grøvdal, L., Grandal, M. et al. Histochem Cell Biol 2008 129: 563. doi:10.1007-s00418-008-0401-3

Abstract

ErbB receptors EGFR ErbB1, ErbB2, ErbB3, and ErbB4 are important regulators of normal growth and differentiation, and they are involved in the pathogenesis of cancer. Following ligand binding and receptor activation, EGFR is endocytosed and transported to lysosomes where the receptor is degraded. This downregulation of EGFR is a complex and tightly regulated process. The functions of ErbB2, ErbB3, and ErbB4 are also regulated by endocytosis to some extent, although the current knowledge of these processes is sparse. Impaired endocytic downregulation of signaling receptors is frequently associated with cancer, since it can lead to increased and uncontrolled receptor signaling. In this review we describe the current knowledge of ErbB receptor endocytic downregulation. In addition, we outline how ErbB receptors can escape endocytic downregulation in cancer, and we discuss how targeted anti-cancer therapy may induce endocytic downregulation of ErbB receptors.

KeywordsEpidermal growth factor receptor Endocytosis Lysosomal degradation ErbB2 Ubiquitin Endosomal sorting  Download fulltext PDF



Autor: Kirstine Roepstorff - Lene Grøvdal - Michael Grandal - Mads Lerdrup - Bo van Deurs

Fuente: https://link.springer.com/







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