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BMC Cancer

, 16:562

Epidemiology, prevention and public health


BackgroundCoffee contains biologically-active substances that suppress carcinogenesis in vivo, and coffee consumption has been associated with a lower risk of malignant melanoma. We studied the impact of total coffee consumption and of different brewing methods on the incidence of malignant melanoma in a prospective cohort of Norwegian women.

MethodsWe had baseline information on total coffee consumption and consumption of filtered, instant, and boiled coffee from self-administered questionnaires for 104,080 women in the Norwegian Women and Cancer NOWAC Study. We also had follow-up information collected 6–8 years after baseline. Multiple imputation was used to deal with missing data, and multivariable Cox regression models were used to calculate hazard ratios HR for malignant melanoma by consumption category of total, filtered, instant, and boiled coffee.

ResultsDuring 1.7 million person-years of follow-up, 762 cases of malignant melanoma were diagnosed. Compared to light consumers of filtered coffee ≤1 cup-day, we found a statistically significant inverse association with low-moderate consumption >1–3 cups-day, HR = 0.80; 95 % confidence interval CI 0.66–0.98 and high-moderate consumption of filtered coffee >3–5 cups-day, HR = 0.77; 95 % CI 0.61–0.97 and melanoma risk ptrend = 0.02. We did not find a statistically significant association between total, instant, or boiled coffee consumption and the risk of malignant melanoma in any of the consumption categories.

ConclusionsThe data from the NOWAC Study indicate that a moderate intake of filtered coffee could reduce the risk of malignant melanoma.

KeywordsCoffee Filtered Instant Boiled Melanoma Prospective cohort Multiple imputation Electronic supplementary materialThe online version of this article doi:10.1186-s12885-016-2586-5 contains supplementary material, which is available to authorized users.

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Autor: Marko Lukic - Mie Jareid - Elisabete Weiderpass - Tonje Braaten


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