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BMC Cancer

, 8:26

First Online: 29 January 2008Received: 22 October 2007Accepted: 29 January 2008DOI: 10.1186-1471-2407-8-26

Cite this article as: Quero, L., Mongiat-Artus, P., Ravery, V. et al. BMC Cancer 2008 8: 26. doi:10.1186-1471-2407-8-26

Abstract

BackgroundTo assess the efficacy of salvage radiotherapy RT for persistent or rising PSA after radical prostatectomy and to determine prognostic factors identifying patients who may benefit from salvage RT.

MethodsBetween 1990 and 2003, 59 patients underwent RT for PSA recurrence after radical prostatectomy. Patients received a median of 66 Gy to the prostate bed with 3D or 2D RT. The main end point was biochemical failure after salvage RT, defined as an increase of the serum PSA value >0.2 ng-ml confirmed by a second elevation.

ResultsMedian follow-up was 38 months. The 3-year and 5-year bDFS rates were 56.1% and 41.2% respectively. According to multivariate analysis, only preRT PSA ≥1 ng-ml was associated with biochemical relapse.

ConclusionWhen delivered early, RT is an effective treatment after radical prostatectomy. Only preRT PSA ≥1 ng-ml predicted relapse.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-8-26 contains supplementary material, which is available to authorized users.

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Autor: Laurent Quero - Pierre Mongiat-Artus - Vincent Ravery - Claude Maylin - François Desgrandchamps - Christophe Hennequin

Fuente: https://link.springer.com/







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