EEG Radiotelemetry in Small Laboratory Rodents: A Powerful State-of-the Art Approach in Neuropsychiatric, Neurodegenerative, and Epilepsy ResearchReport as inadecuate

EEG Radiotelemetry in Small Laboratory Rodents: A Powerful State-of-the Art Approach in Neuropsychiatric, Neurodegenerative, and Epilepsy Research - Download this document for free, or read online. Document in PDF available to download.

Neural Plasticity - Volume 2016 2016, Article ID 8213878, 19 pages -

Review Article

Department of Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices, 53175 Bonn, Germany

Institute of Physiology, University Medical Center Mainz, 55128 Mainz, Germany

Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Cologne, 50924 Cologne, Germany

German Center for Neurodegenerative Diseases, 53175 Bonn, Germany

Received 8 July 2015; Accepted 27 August 2015

Academic Editor: James M. Wyss

Copyright © 2016 Andreas Lundt et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


EEG radiotelemetry plays an important role in the neurological characterization of transgenic mouse models of neuropsychiatric and neurodegenerative diseases as well as epilepsies providing valuable insights into underlying pathophysiological mechanisms and thereby facilitating the development of new translational approaches. We elaborate on the major advantages of nonrestraining EEG radiotelemetry in contrast to restraining procedures such as tethered systems or jacket systems containing recorders. Whereas a main disadvantage of the latter is their unphysiological, restraining character, telemetric EEG recording overcomes these disadvantages. It allows precise and highly sensitive measurement under various physiological and pathophysiological conditions. Here we present a detailed description of a straightforward successful, quick, and efficient technique for intraperitoneal as well as subcutaneous pouch implantation of a standard radiofrequency transmitter in mice and rats. We further present computerized 3D-stereotaxic placement of both epidural and deep intracerebral electrodes. Preoperative preparation of mice and rats, suitable anaesthesia, and postoperative treatment and pain management are described in detail. A special focus is on fields of application, technical and experimental pitfalls, and technical connections of commercially available radiotelemetry systems with other electrophysiological setups.

Author: Andreas Lundt, Carola Wormuth, Magdalena Elisabeth Siwek, Ralf Müller, Dan Ehninger, Christina Henseler, Karl Broich, Anna



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