The CCR5Δ32 rs333 polymorphism is not a predisposing factor for severe pandemic influenza in the Brazilian admixed populationReportar como inadecuado




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BMC Research Notes

, 8:326

InfectiousDiseases

Abstract

BackgroundRecent studies have tried to identify host genetic variants that could explain severe cases and deaths in infection with Influenza AH1N1pdm09, especially among children and young adults. CCR5 is a chemokine receptor expressed on T cells, macrophages and dendritic cells, which is an important mediator of leukocyte chemotaxis during the immune response. A deletion mutation Δ32 in this gene interferes with the response of immune cells, impairing viral clearance. We evaluated the CCR5Δ32 polymorphism rs333 in individuals of the Brazilian admixed population with a diagnosis of Influenza AH1N1pdm09 infection.

MethodsA total of 330 subjects with a diagnosis of Influenza AH1N1pdm09, evaluated at health services in the northern and northeastern regions of Brazil between June 2009 and August 2010, were genotyped for the Δ32 deletion rs333. The cases were classified according to the progression of infection into a group of hospitalized patients n = 156 and a group of non-hospitalized patients n = 174.

ResultsNo significant differences in the allele or genotype frequencies of the CCR5Δ32 polymorphism were observed between non-hospitalized and hospitalized patients p = 0.289 and p = 0.431, respectively.

ConclusionThe Δ32 deletion in the CCR5 gene is not associated with an unfavorable outcome in patients infected with Influenza AH1N1pdm09 in the Brazilian admixed population.

KeywordsAH1N1pdm09 infection Influenza CCR5Δ32 AbbreviationsCDCCenters for Disease Control and Prevention

IECEvandro Chagas Institute

SEVIRVirology Section

WHOWorld Health Organization

Electronic supplementary materialThe online version of this article doi:10.1186-s13104-015-1299-1 contains supplementary material, which is available to authorized users.

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Autor: Alvino Maestri - Mirleide Cordeiro dos Santos - Elzemar M Ribeiro-Rodrigues - Wyller Alencar de Mello - Rita Catarina Med

Fuente: https://link.springer.com/







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