EXercise to prevent AnthrCycline-based Cardio-Toxicity EXACT in individuals with breast or hematological cancers: a feasibility study protocolReportar como inadecuado




EXercise to prevent AnthrCycline-based Cardio-Toxicity EXACT in individuals with breast or hematological cancers: a feasibility study protocol - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Pilot and Feasibility Studies

, 2:44

First Online: 05 August 2016Received: 11 February 2016Accepted: 23 June 2016DOI: 10.1186-s40814-016-0084-9

Cite this article as: Keats, M.R., Grandy, S.A., Giacomantonio, N. et al. Pilot Feasibility Stud 2016 2: 44. doi:10.1186-s40814-016-0084-9

Abstract

BackgroundAnthracyclines AC, widely used and effective anticancer agents, are known to induce both acute and chronic declines in cardiovascular health, ranging in severity from asymptomatic, subclinical dysfunction to substantial cardiomyopathy leading to congestive heart failure and death. There is substantial evidence that physical activity, higher levels of cardiorespiratory fitness, and exercise therapy can help prevent cardiovascular disease. Moreover, animal studies have shown that exercise performed concomitantly with AC treatment may attenuate early cardiac damage that results from AC exposure. Our primary objective is to assess the feasibility of a 12-week aerobic exercise training AET program in patients receiving AC-based chemotherapy.

Methods-designThis is a prospective, single-arm pre-post-test design, feasibility study of a supervised 12-week progressive, light-to-moderate to moderate-to-vigorous intensity AET program for patients 18–65 years receiving AC chemotherapeutic treatment for a primary-non-recurrent breast cancer or hematological malignancy. Both feasibility e.g., participant recruitment, program adherence, safety and intervention outcome e.g., biological markers of cardiotoxicity, aerobic capacity, quality of life measures will be collected. The AET program will include two, 45-min community-based exercise sessions treadmill or cycle per week for a total of 12 weeks. All exercise sessions will be supervised by trained exercise specialists.

DiscussionData from the EXACT study will be evaluated to determine the need to refine patient recruitment methods and general acceptability of the AET program. Preliminary data on the effects of the AET intervention on pertinent cardiac and health outcomes will also be evaluated and used to inform future studies in terms of the most appropriate outcome measures to adopt and sample size estimation.

Trial registrationClinicalTrails.gov, NCT02471053

KeywordsFeasibility study Breast cancer Hematological cancer Aerobic exercise training Cardiotoxicity Anthracyclines  Download fulltext PDF



Autor: Melanie R. Keats - Scott A. Grandy - Nicholas Giacomantonio - David MacDonald - Miroslaw Rajda - Tallal Younis

Fuente: https://link.springer.com/







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