Modeling the effect of PTPN22in rheumatoid arthritisReport as inadecuate

Modeling the effect of PTPN22in rheumatoid arthritis - Download this document for free, or read online. Document in PDF available to download.

BMC Proceedings

, 1:S37

First Online: 18 December 2007DOI: 10.1186-1753-6561-1-S1-S37

Cite this article as: Bourgey, M., Perdry, H. & Clerget-Darpoux, F. BMC Proc 2007 1Suppl 1: S37. doi:10.1186-1753-6561-1-S1-S37


In order to model the effect of PTPN22 on rheumatoid arthritis RA, we determined the combination of single-nucleotide-polymorphisms SNPs showing the strongest association with RA. Three SNPs rs2476601-rs12730735-rs11102685 were selected for which we estimated the genotypic relative risks GRRs of the corresponding genotypes. On the basis of these GRRs we defined four at-risk genotypic classes. Relative to the class of reference risk, individuals had a risk approximately multiplied by two, three, or four. This classification was confirmed by the excess of identity-by-descent IBD sharing IBD = 2 for the sibs of an index in the high-risk class and by excess of non-IBD sharing IBD = 0 when the index belonged to the low-risk class. The observed data could not be explained by the role of a single variant but were compatible either with a joint effect of the three typed SNPs of PTPN22 on RA or with the role of two untyped variants.

Download fulltext PDF

Author: Mathieu Bourgey - Hervé Perdry - Françoise Clerget-Darpoux


Related documents