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Theoretical Biology and Medical Modelling

, 12:15

First Online: 04 September 2015Received: 08 June 2015Accepted: 27 August 2015DOI: 10.1186-s12976-015-0014-1

Cite this article as: Khor, B.Y., Tye, G.J., Lim, T.S. et al. Theor Biol Med Model 2015 12: 15. doi:10.1186-s12976-015-0014-1


Protein structure prediction from amino acid sequence has been one of the most challenging aspects in computational structural biology despite significant progress in recent years showed by critical assessment of protein structure prediction CASP experiments. When experimentally determined structures are unavailable, the predictive structures may serve as starting points to study a protein. If the target protein consists of homologous region, high-resolution typically <1.5 Å model can be built via comparative modelling. However, when confronted with low sequence similarity of the target protein also known as twilight-zone protein, sequence identity with available templates is less than 30 %, the protein structure prediction has to be initiated from scratch. Traditionally, twilight-zone proteins can be predicted via threading or ab initio method. Based on the current trend, combination of different methods brings an improved success in the prediction of twilight-zone proteins. In this mini review, the methods, progresses and challenges for the prediction of twilight-zone proteins were discussed.

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Author: Bee Yin Khor - Gee Jun Tye - Theam Soon Lim - Yee Siew Choong



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