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BMC Cancer

, 16:691

Epidemiology, prevention and public health

Abstract

BackgroundMelanoma accounts for the majority of skin cancer deaths. It has over thirty different subtypes. Different races have been observed to differ in multiple aspects of melanoma.

MethodsSEER Surveillance, Epidemiology, and End Results data on six major subtypes, namely melanoma in situ MIS, superficial spreading melanoma SSM, nodular melanoma NM, lentigo maligna melanoma LMM, acral lentiginous melanoma malignant ALM, and malignant melanoma NOS NOS, were analyzed. The racial groups studied included NHW non-Hispanic white, HW Hispanic white, Black, and Asian-PI Pacific Islanders. Univariate and multivariate analysis was conducted to quantify racial differences in patients’ characteristics, incidence, treatment, and survival.

ResultsSignificant racial differences are observed in patients’ characteristics. For all subtypes except for ALM, NHWs have the highest incidence rates, followed by HWs, while Blacks have the lowest. For ALM, HWs have the highest rate, followed by NHWs. In stratified analysis, interaction between gender and race is observed. For the first five subtypes and localized and regional NOS, the dominating majority of patients had surgery, while for distant NOS, the distribution of treatment is more scattered. Significant racial differences are observed for distant ALM and NOS. For MIS, SSM, NM, LMM, and ALM, there is no significant racial difference in survival. For NOS, significant racial differences in survival are observed for the localized and regional stages, with NHWs having the best and Blacks having the worst five-year survival rates.

ConclusionsRacial differences exist for the six major melanoma subtypes in the U.S. More data collection and analysis are needed to fully describe and interpret the differences across racial groups and across subtypes.

KeywordsMelanoma Racial difference Subtype SEER AbbreviationsALMAcral lentiginous melanoma malignant

Asian-PIAsian and Pacific Islanders

HWHispanic white

LMMLentigo maligna melanoma

MISMelanoma in situ

NHWNon-Hispanic white

NMNodular melanoma

NOSMalignant melanoma NOS

SSMSuperficial spreading melanoma

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Autor: Yu Wang - Yinjun Zhao - Shuangge Ma

Fuente: https://link.springer.com/







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