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Cell Regeneration

, 4:6

First Online: 03 October 2015Received: 18 June 2015Accepted: 29 August 2015DOI: 10.1186-s13619-015-0021-z

Cite this article as: Cheung, HH., Pei, D. & Chan, WY. Cell Regen 2015 4: 6. doi:10.1186-s13619-015-0021-z


Aging is considered an irreversible biological process and also a major risk factor for a spectrum of geriatric diseases. Advanced age-related decline in physiological functions, such as neurodegeneration, development of cardiovascular disease, endocrine and metabolic dysfunction, and neoplastic transformation, has become the focus in aging research. Natural aging is not regarded as a programmed process. However, accelerated aging due to inherited genetic defects in patients of progeria is programmed and resembles many aspects of natural aging. Among several premature aging syndromes, Werner syndrome WS and Hutchinson–Gilford progeria syndrome HGPS are two broadly investigated diseases. In this review, we discuss how stem cell aging in WS helps us understand the biology of aging. We also discuss briefly how the altered epigenetic landscape in aged cells can be reversed to a -juvenile- state. Lastly, we explore the potential application of the latest genomic editing technique for stem cell-based therapy and regenerative medicine in the context of aging.

KeywordsWerner syndrome Stem cells Aging WRN  Download fulltext PDF

Autor: Hoi-Hung Cheung - Duanqing Pei - Wai-Yee Chan


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