Pathogenesis of Bone Diseases: The Role of Immune SystemReportar como inadecuado

Pathogenesis of Bone Diseases: The Role of Immune System - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of Immunology Research - Volume 2015 2015, Article ID 785845, 2 pages -


Section of Human Anatomy and Histology, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, 70124 Bari, Italy

Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy

Section of Gerontology and Bone Metabolism Diseases, Department of Medical Science, University of Torino, 10126 Torino, Italy

Department of Orthopedics, Washington University School of Medicine, St. Louis, MO 63110, USA

Received 15 February 2015; Accepted 15 February 2015

Copyright © 2015 Giacomina Brunetti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Bone is a metabolically active tissue that undergoes continuous remodeling by two sequential events, bone formation and resorption. These events are strongly linked and tightly regulated to maintain skeletal homeostasis. The bone cells responsible for the dual events include the bone-resorbing cells, the osteoclasts, arising from monocyte-macrophage precursors, and the bone forming cells, the osteoblasts, having a mesenchymal origin. Immune and bone cell activities are linked by several pathways 1 and the former can promote bone building or destruction. Further, immune cells can be involved in the mineralization process occurring in extra-skeletal sites. In this special issue different authors highlighted these items both through research articles and reviews.

In detail, interaction between osteoblast precursors, the mesenchymal stem cells MSCs 2, and immune cells during fracture repair acts as one of the key factors governing successful bone healing. Additionally, bone damage following immune deregulation may be local as in arthritis and periodontal disease PD or systemic as in osteoporosis 3 and osteotropic cancers 4, 5. It could be multifactorial and thus due to genetic modifications i.e., Gaucher disease as well as to lipopolysaccharide- LPS- mediated release of inflammatory cytokines i.e., PD, osteomyelitis, and arthritis, and so forth. New insights suggest that, in immune-mediated bone diseases, bone resorption active phases are characterized by increased levels of immunoreceptor tyrosine-based activation motifs ITAMs; these molecules together with OSCAR could be indicative of disease progression. Further, osteotropic cancer-related immune alterations showed distinct immune cell phenotype as observed in chronic myeloid leukemia, multiple myeloma, and bone metastatic solid tumors.

State-of-the-art and new mechanisms are clearly described in this special issue; they can be useful for the identification of new therapeutic targets and bone disease markers.

Giacomina BrunettiGiorgio MoriPatrizia D’AmelioRoberta Faccio


G. Mori, P. D-Amelio, R. Faccio, and G. Brunetti -The interplay between the bone and the immune system,- Clinical and Developmental Immunology, vol. 2013, Article ID 720504, 16 pages, 2013. View at Publisher · View at Google Scholar · View at ScopusG. Mori, M. Centonze, G. Brunetti et al. -Osteogenic properties of human dental pulp stem cells,- Journal of Biological Regulators and Homeostatic Agents, vol. 24, no. 2, pp. 167–175, 2010. View at Google Scholar · View at ScopusP. D-Amelio, A. Grimaldi, S. di Bella et al. -Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: a key mechanism in osteoporosis,- Bone, vol. 43, no. 1, pp. 92–100, 2008. View at Publisher · View at Google Scholar · View at ScopusG. Brunetti, G. Colaianni, M. F. Faienza, S. Colucci, and M. Grano -Osteotropic cancers: from primary tumor to bone,- Clinical Reviews in Bone and Mineral Metabolism, vol. 11, no. 3-4, pp. 94–102, 2013. View at Publisher · View at Google Scholar · View at ScopusI. Roato -Interaction among cells of bone, immune system, and solid tumors leads to bone metastases,- Clinical and Developmental Immunology, vol. 2013, Article ID 315024, 7 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus

Autor: Giacomina Brunetti, Giorgio Mori, Patrizia D’Amelio, and Roberta Faccio



Documentos relacionados