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BMC Research Notes

, 8:530

Cancer

Abstract

BackgroundRecently women’s lung cancer mortality rates have dramatically increased in developed countries, contrasting with a levelling off or decrease among men. Descriptive epidemiological data on primary lung cancer in women is scarce in Morocco. The aim of this study, conducted in the National Institute of Oncology in Rabat, was to describe the epidemiological profiling especially for the smoking status, to determine the most frequent type of lung cancer, and to analyse the survival of Moroccan women with lung cancer diagnosis.

ResultsWe found 101 women among 1680 male and female cases of lung cancer. The never-smokers were estimated to 75 %. The proportion of adenocarcinoma among never and passive smokers was higher than that of squamous cell carcinoma SCC 69.4 versus 30.6 %, while among women who were smokers, the most frequent histological type was SCC 63.6 %. The Cox regression analysis showed that smoking and passive smoking were not significantly associated with survival HR: 0.62 95 % CI 0.31, 1.30; p = 0.19 HR: 0.56 95 % CI 0.29, 1.08; p = 0.08 respectively. Adenocarcinoma was significantly associated with shorter survival HR: 1.73 95 % CI 1.05, 2.85; p = 0.03.

ConclusionsThe majority Moroccan women affected by lung cancer have never smoked 75 %. Environmental exposures, genetic predisposition, hormonal factors, and viral infection may all play a role in lung cancer in this category. The relation between histological type and tobacco found in our series concurred with those reported in the literature—adenocarcinoma appears to be the most frequent cell type affecting never and passive smokers. Adenocarcinoma is significantly associated with poorer survival.

KeywordsLung cancer Women Survival AbbreviationsHRhazard ratio

CTcomputed tomography

TNMtumor, nodes and metastasis

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Autor: Fatima Az-zahra Zakkouri - Ouaouch Saloua - Abahssain Halima - Razine Rachid - Mrabti Hind - Errihani Hassan

Fuente: https://link.springer.com/







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