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BMC Public Health

, 7:328

First Online: 14 November 2007Received: 11 July 2007Accepted: 14 November 2007DOI: 10.1186-1471-2458-7-328

Cite this article as: Hosseinpanah, F., Rambod, M. & Azizi, F. BMC Public Health 2007 7: 328. doi:10.1186-1471-2458-7-328


BackgroundLittle evidence exists regarding the magnitude of contribution of excess weight to diabetes in the Middle East countries. This study aimed at quantification of the impact of overweight and obesity on the incidence of type 2 diabetes mellitus T2DM at a population level in Tehran, Iran.

MethodsUsing data of a population-based short-term cohort study in Iran, which began in 1997 with 3.6-year follow-up, we calculated the adjusted odds ratios OR and population attributable risks PAR of developing T2DM, i.e. the proportion of diabetes that could have been avoided had overweight and-or obesity not been present in the population.

ResultsOf the 4728 subjects studied, aged ≥ 20 years, during the 3.6-year follow-up period, 3.8% n = 182 developed T2DM. This proportion was 1.4%, 3.6%, and 7.8% for the normal, overweight, and obese subjects, respectively. When compared to normal BMI, the adjusted ORs for incident diabetes were 1.76 95% confidence interval CI 1.07 to 2.89 for overweight and 3.54 95% CI 2.16 to 5.79 for obesity. The PARs adjusted for family history of diabetes, age, triglycerides, systolic blood pressure was 23.3% for overweight and 37.1% for obesity. These figures were 7.8% and 26.6% for men and 35.3% and 48.3% for women, respectively.

ConclusionIncident T2DM is mainly attributable to excess weight, significantly more so in Tehranian women than men. Nonetheless, the contribution of excess weight in developing T2DM was lower in our short-term study than that reported in long-term periods. This probably reflects the significant role of other risk factors of T2DM in a short-term follow-up. Hence, prevention of excess weight probably should be considered as a major strategy for reducing incidence of T2DM; the contribution of other risk factors in developing T2DM in short-term period deserve to be studied and be taken into account.

Abbreviations2h-PG2-hour postchallenge Plasma Glucose

ANOVAAnalysis Of Variance

BMIBody Mass Index

CVDCardiovascular Disease

DBPDiastolic Blood Pressure

FPGFasting Plasma Glucose

HDL-CHigh Density Lipoprotein – Cholesterol

LDL-CLow Density Lipoprotein – Cholesterol

OGTTOral Glucose Tolerance Test

PARPopulation Attributable Risk

SBPSystolic Blood Pressure

SDStandard Deviation

T2DMType 2 Diabetes Mellitus

TCTotal Cholesterol


TLGSTehran Lipid and Glucose Study

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2458-7-328 contains supplementary material, which is available to authorized users.

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Author: Farhad Hosseinpanah - Mehdi Rambod - Fereidoun Azizi

Source: https://link.springer.com/

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