Comparison of Zn, Cu, and Fe Content in Hair and Serum in Alopecia Areata Patients with Normal GroupReportar como inadecuado




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Dermatology Research and Practice - Volume 2014 2014, Article ID 784863, 5 pages -

Research Article

Molecular Dermatology Research Center, Dermatology Department, Shiraz University of Medical Sciences, Shiraz, Iran

Maternal-Fetal Medicine Research Center, Hafez Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

Recombinant Protein Laboratory, Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Iran

Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

Department of Biology, Shiraz University, Shiraz, Iran

Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran

Received 15 June 2014; Accepted 10 August 2014; Published 27 August 2014

Academic Editor: Craig G. Burkhart

Copyright © 2014 Ladan Dastgheib et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Alopecia areata AA is an autoimmune condition, in which hair is lost from some areas of the body. Though its etiopathogenesis is not fully understood, there are claims that imbalance of trace elements may trigger the onset of AA, by distorting immune functions. In this study, we tried to investigate the relationship between AA and iron, zinc, and copper levels of serum and hair. Materials and Methods. Sixteen female patients with AA 14–40 years old and 27 healthy female controls were enrolled in this study. Serum and hair level of iron, zinc, and copper were measured by flame emission spectroscopy. The resulting data was analyzed with SPSS15. Results. We did not detect a significant difference in the serum and hair level of iron, zinc, and copper between patients and controls. There was a significant correlation between serum and hair level of iron ,  , zinc ,  , and copper , in patients and controls. Discussion and Conclusion. According to this study, there was no statistically significant difference between trace elements among AA patients and controls. So the trace elements level in hair and serum may not be relevant to the immunologic dysfunction that exists in AA patients.





Autor: Ladan Dastgheib, Zohreh Mostafavi-pour, Ahmad Adnan Abdorazagh, Zahra Khoshdel, Maryam Sadat Sadati, Iman Ahrari, Sajjad Ahr

Fuente: https://www.hindawi.com/



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