Malignant mesothelioma of the pleura with desmoplastic histology: a case series and literature reviewReportar como inadecuado

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BMC Cancer

, 16:718

Medical and radiation oncology


BackgroundDesmoplastic malignant pleural mesothelioma DMM is rare histological subtype of diffuse malignant pleural mesothelioma MPM, accounting for 5–10 % of cases. It has a poor prognosis, with direct invasion of the chest wall or lungs and distant metastases. Its pathological characteristics include dense collagen fibers in a storiform pattern. Its pretreatment pathological diagnosis is difficult, with fibrous pleuritis and reactive mesothelial hyperplasia as potential differential diagnoses.

Case presentationWe retrospectively reviewed the medical charts of patients with MPM from 1996 to 2012. Among 60 patients with MPM, four patients with the desmoplastic subtype were identified and their clinical characteristics, including asbestos exposure, treatment, and prognosis, were reviewed. All of the patients with DMM were men, with a median age of 69 years range: 63–74 years. All four patients had been exposed to asbestos. The definitive diagnosis was made histologically and the International Mesothelioma Interest Group classification was advanced III-IV: 2-3 in all four patients. Three patients were treated with chemotherapy two with cisplatin-pemetrexed and one with cisplatin-gemcitabine and one patient underwent surgery. The median survival time in the patients with DMM was 3.8 months range: 0.9–11.5 months, compared with 10.5 months in patients with other subtypes of MPM in our institution.

ConclusionsDMM continues to have a poor prognosis. It is important to recognize this variant and distinguish it from pleural plaques, non-specific reactive pleural fibrosis, pleurisy, and other lung diseases.

KeywordsDesmoplastic Mesothelioma Chemotherapy Prognosis AbbreviationsDMMDesmoplastic malignant mesothelioma


MPMMalignant pleural mesothelioma

Electronic supplementary materialThe online version of this article doi:10.1186-s12885-016-2745-8 contains supplementary material, which is available to authorized users.

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Autor: Kana Hashimoto - Yusuke Okuma - Yukio Hosomi - Tsunekazu Hishima


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