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BMC Medicine

, 14:130

First Online: 07 September 2016Received: 29 April 2016Accepted: 20 August 2016DOI: 10.1186-s12916-016-0678-3

Cite this article as: Ajelli, M., Merler, S., Fumanelli, L. et al. BMC Med 2016 14: 130. doi:10.1186-s12916-016-0678-3

Abstract

BackgroundAmong the three countries most affected by the Ebola virus disease outbreak in 2014–2015, Guinea presents an unusual spatiotemporal epidemic pattern, with several waves and a long tail in the decay of the epidemic incidence.

MethodsHere, we develop a stochastic agent-based model at the level of a single household that integrates detailed data on Guinean demography, hospitals, Ebola treatment units, contact tracing, and safe burial interventions. The microsimulation-based model is used to assess the effect of each control strategy and the probability of elimination of the epidemic according to different intervention scenarios, including ring vaccination with the recombinant vesicular stomatitis virus-vectored vaccine.

ResultsThe numerical results indicate that the dynamics of the Ebola epidemic in Guinea can be quantitatively explained by the timeline of the implemented interventions. In particular, the early availability of Ebola treatment units and the associated isolation of cases and safe burials helped to limit the number of Ebola cases experienced by Guinea. We provide quantitative evidence of a strong negative correlation between the time series of cases and the number of traced contacts. This result is confirmed by the computational model that suggests that contact tracing effort is a key determinant in the control and elimination of the disease. In data-driven microsimulations, we find that tracing at least 5–10 contacts per case is crucial in preventing epidemic resurgence during the epidemic elimination phase. The computational model is used to provide an analysis of the ring vaccination trial highlighting its potential effect on disease elimination.

ConclusionsWe identify contact tracing as one of the key determinants of the epidemic’s behavior in Guinea, and we show that the early availability of Ebola treatment unit beds helped to limit the number of Ebola cases in Guinea.

KeywordsComputational modeling Intervention strategies Ebola epidemiology AbbreviationsCTContact tracing

ETUEbola treatment unit

HCWHealth care worker

EVDEbola virus disease

GMoHGuinean ministry of health

CIConfidence interval

Electronic supplementary materialThe online version of this article doi:10.1186-s12916-016-0678-3 contains supplementary material, which is available to authorized users.

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Autor: Marco Ajelli - Stefano Merler - Laura Fumanelli - Ana Pastore y Piontti - Natalie E. Dean - Ira M. LonginiJr. - M. Elizab

Fuente: https://link.springer.com/







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