Guidelines for Evaluation and Management of Cognitive Disorders in HIV-Positive IndividualsReportar como inadecuado




Guidelines for Evaluation and Management of Cognitive Disorders in HIV-Positive Individuals - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Current HIV-AIDS Reports

, Volume 13, Issue 5, pp 235–240

Topical Collection on Central Nervous System and Cognition

Abstract

Antiretroviral therapy has revolutionised the treatment for people living with HIV PLWH. Where antiretroviral coverage is high, the treatment paradigm for HIV-disease is now one of managing the long-term consequences of the virus and its treatment rather than the consequences of untreated HIV-disease such as immunosuppression and opportunistic infections. One such long-term consequence is HIV-associated cognitive impairment which is reported to occur in up to 50 % of treated PLWH and has been associated with poorer outcomes. Given the ageing cohort and increased frequency of comorbidities, the prevalence of symptomatic cognitive impairment may increase with time. High quality evidence for management strategies including screening, diagnosis and treatment of HIV-associated cognitive impairment are lacking and in general guidelines are based on best clinical practice. In this article, we assessed recent guidelines concerning the management of HIV-associated cognitive impairment by performing a systematic review of the MEDLINE database using PubMed. We report that, in general, guidelines from around the world regarding the management of HIV-associated cognitive impairment are converging. Screening is generally not recommended in asymptomatic PLWH. Diagnosis of HIV-associated cognitive impairment should be made only after a comprehensive assessment and exclusion of other potential causes. Antiretroviral therapy forms the cornerstone of management of HIV-associated cognitive impairment and should be guided by plasma and cerebrospinal fluid CSF genotypes.

KeywordsHIV-associated cognitive disorder Cognitive impairment HIV Guidelines This article is part of the Topical Collection on Central Nervous System and Cognition

Download fulltext PDF



Autor: Jonathan Underwood - Alan Winston

Fuente: https://link.springer.com/







Documentos relacionados