Non-alcoholic beverages and risk of bladder cancer in UruguayReportar como inadecuado

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BMC Cancer

, 7:57

First Online: 29 March 2007Received: 27 February 2006Accepted: 29 March 2007DOI: 10.1186-1471-2407-7-57

Cite this article as: De Stefani, E., Boffetta, P., Deneo-Pellegrini, H. et al. BMC Cancer 2007 7: 57. doi:10.1186-1471-2407-7-57


BackgroundBladder cancer is the fourth most frequent malignancy among Uruguayan men. A previous study from Uruguay suggested a high risk of bladder cancer associated with maté drinking. We conducted an additional case-control study in order to further explore the role of non-alcoholic beverages in bladder carcinogenesis.

MethodsIn the time period 1996–2000, 255 incident cases with transitional cell carcinoma of the bladder and 501 patients treated in the same hospitals and in the same time period were frequency matched on age, sex, and residence. Both cases and controls were face-to-face interviewed on occupation, tobacco smoking, alcohol drinking and intake of maté, coffee, tea, and soft drinks. Statistical analysis was carried out by unconditional multiple logistic regression.

ResultsEver maté drinking was positively associated with bladder cancer odds ratio OR 2.2, 95% confidence interval CI 1.2–3.9 and the risk increased for increasing duration and amount of maté drinking. Both coffee and tea were strongly associated with bladder cancer risk OR for coffee drinking 1.6, 95% CI 1.2–2.3; OR for tea drinking 2.3, 95% CI 1.5–3.4. These results were confirmed in a separate analysis of never-smokers.

ConclusionOur results suggest that drinking of maté, coffee and tea may be risk factors for bladder carcinoma in Uruguay.

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Autor: Eduardo De Stefani - Paolo Boffetta - Hugo Deneo-Pellegrini - Pelayo Correa - Alvaro L Ronco - Paul Brennan - Gilles Ferro


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