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Annals of Biomedical Engineering

, Volume 44, Issue 1, pp 58–70

First Online: 30 September 2015Received: 02 June 2015Accepted: 24 September 2015DOI: 10.1007-s10439-015-1474-5

Cite this article as: Crozier, A., Augustin, C.M., Neic, A. et al. Ann Biomed Eng 2016 44: 58. doi:10.1007-s10439-015-1474-5


Computational models of cardiac electromechanics EM are increasingly being applied to clinical problems, with patient-specific models being generated from high fidelity imaging and used to simulate patient physiology, pathophysiology and response to treatment. Current structured meshes are limited in their ability to fully represent the detailed anatomical data available from clinical images and capture complex and varied anatomy with limited geometric accuracy. In this paper, we review the state of the art in image-based personalization of cardiac anatomy for biophysically detailed, strongly coupled EM modeling, and present our own tools for the automatic building of anatomically and structurally accurate patient-specific models. Our method relies on using high resolution unstructured meshes for discretizing both physics, electrophysiology and mechanics, in combination with efficient, strongly scalable solvers necessary to deal with the computational load imposed by the large number of degrees of freedom of these meshes. These tools permit automated anatomical model generation and strongly coupled EM simulations at an unprecedented level of anatomical and biophysical detail.

KeywordsMesh Myocardial fiber architecture Finite element High performance computing Strong scaling Associate Editor Scott I. Simon oversaw the review of this article.

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Autor: A. Crozier - C. M. Augustin - A. Neic - A. J. Prassl - M. Holler - T. E. Fastl - A. Hennemuth - K. Bredies - T. Kuehne


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