Risk of adverse pregnancy outcomes in women with periodontal disease and the effectiveness of interventions in decreasing this risk: protocol for systematic overview of systematic reviewsReport as inadecuate

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Systematic Reviews

, 5:16

First Online: 01 February 2016Received: 27 July 2015Accepted: 21 January 2016DOI: 10.1186-s13643-016-0195-7

Cite this article as: Vanterpool, S.F., Tomsin, K., Reyes, L. et al. Syst Rev 2016 5: 16. doi:10.1186-s13643-016-0195-7


BackgroundPeriodontal disease is an inflammatory disease of the tissues supporting the teeth. Women who have periodontal disease while pregnant may be at risk of adverse pregnancy outcomes. Although the association between periodontal disease and adverse pregnancy outcomes has been addressed in a considerable number of systematic reviews and meta-analyses, there are important differences in the conclusions of these reviews. Systematic reviews assessing the effectivity of various therapeutic interventions to treat periodontal disease during pregnancy to try and reduce adverse pregnancy outcomes have also arrived at different conclusions. We aim to provide a systematic overview of systematic reviews comparing the frequency of adverse pregnancy outcomes between women with and without periodontal disease and-or evaluating the effect of preventive and therapeutic interventions for periodontal disease before or during pregnancy on adverse pregnancy outcomes.

MethodsWe will include systematic reviews reporting on studies comparing adverse pregnancy outcomes: i between women with or without periodontal disease before <6 months or during pregnancy and-or ii according to preventive or therapeutic interventions for periodontal disease. Eligible interventions include combinations of the following: oral hygiene education, use of antibiotics, subgingival scaling, and root planing. For preventive and-or therapeutic reviews, the following comparisons will be considered: no intervention, a placebo intervention, or an alternative intervention. Our primary adverse pregnancy outcomes of interests are maternal mortality, preterm delivery, and perinatal mortality. Two reviewers will independently identify eligible published and unpublished systematic reviews from six electronic databases and using hand searching of reference lists and citations. Data items extracted from included systematic reviews are based on the Cochrane Effective Practice and Organization of Care checklist and the preferred reporting items for systematic review and meta-analysis PRISMA statement. In our narrative data synthesis, we will consider risk of bias of individual reviews, focusing mainly on the conclusions of the highest quality reviews using the assessment of multiple systematic reviews AMSTAR checklist. Disagreements during search, selection, data extraction, and risk of bias assessment will be resolved through discussion and-or consultation of a third reviewer.

Systematic review registrationPROSPERO CRD42015030132

KeywordsPeriodontal disease Periodontitis Pregnancy Adverse pregnancy outcome Preterm birth Perinatal mortality Maternal mortality Treatment Systematic review Overview AbbreviationsAIMAfrican Index Medicus

AMSTARassessment of multiple systematic reviews

CBAcontrolled before-and-after

CCAcorrected covered area

CCTclinical controlled trial

CDSRCochrane Database of Systematic Reviews

IMEMRIndex Medicus for the Eastern Mediterranean Region

IMSEARIndex Medicus for South-East Asia Region

ITSinterrupted time series

LILACSLatin American and Caribbean Health Science Literature

MeSHmedical subject headings

PPROMpreterm prelabor rupture of membranes

RCTrandomized controlled trial

SGAsmall for gestational age

WHOWorld Health Organization

WPRIMWestern Pacific Region Index Medicus

Electronic supplementary materialThe online version of this article doi:10.1186-s13643-016-0195-7 contains supplementary material, which is available to authorized users.

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Author: Sizzle F. Vanterpool - Kathleen Tomsin - Leticia Reyes - Luc J. Zimmermann - Boris W. Kramer - Jasper V. Been

Source: https://link.springer.com/

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