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BMC Research Notes

, 9:124

PulmonaryMedicine

Abstract

BackgroundObstructive lung disease OLD, a major global public health problem, has been less investigated in African countries. We assessed the prevalence and determinants of OLD in Yaounde the capital city of Cameroon, using internationally agreed definitions.

MethodsParticipants were adults age >19 years screened during a community-based survey between December 2013 and April 2014. Air flow limitation AFL was based on a pre-bronchodilator forced expiratory volume in 1 s FEV1 and forced vital capacity FVC below the lower limit of normal LLN, AFL–LLN. Chronic obstructive pulmonary disease COPD was based on post-bronchodilator FEV1-FVC ratio < LLN COPD–LLN.

ResultsOf the 1287 subjects included, 51.9 % were female, 9.3 % were current smokers and their mean age was 34.4 ± 12.8 years. Forty-nine 3.8 %, 95 % CI 2.8–4.9 % participants had AFL–LLN. Thirty-one subjects had COPD–LLN; giving a prevalence of COPD–LLN of 2.4 %, 95 % CI 1.6–3.3 %. In multivariable analysis, male gender AOR 2.42; 95 % CI 1.12–5.20 and lifetime wheezing AOR 2.88; 95 % CI 1.06–7.81 were the determinants of COPD-LLN. Otherwise, male sex AOR 1.93, 95 % CI 1.00–3.73, age 40–59 years AOR 1.99, 95 % CI 1.04–3.81 and lifetime wheezing AOR 2.65, 95 % CI 1.13–6.20 remained as independent determinants of AFL–LLN.

ConclusionsObstructive lung disease based on more accurate definitions was relatively infrequent in this population. It is important to sensitize the medical staff and the general public about this condition which should be actively investigated in individuals aged 40 years and above.

KeywordsCOPD Air flow limitation Associated factors Africa AbbreviationsAFLair flow limitation

ATS-ERSAmerican Thoracic Society-European Respiratory Society

COPDchronic obstructive pulmonary disease

EAenumeration areas

FEV1forced expiratory volume in 1 s

FVCforced vital capacity

GOLDglobal initiative for chronic obstructive lung disease

LLNlower limit of normal

OLDobstructive lung disease

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Autor: Eric Walter Pefura-Yone - André Pascal Kengne - Adamou Dodo Balkissou - Christiane Gaelle Magne-Fotso - Martine Ngo-Yong

Fuente: https://link.springer.com/



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