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BMC Cardiovascular Disorders

, 16:211

Epidemiology of gastroenterological disorders


BackgroundPrevention and early detection of arterial stiffness are required to avoid severe cardiovascular events. Recently, new noninvasive arterial stiffness indices, the arterial pressure volume index API and the arterial velocity pulse index AVI, have been developed. The purpose of this study was to examine the clinical validity of these new indices by investigating the association between known risk factors of cardiovascular disease CVD and API or AVI in a large population.

MethodsThis cross-sectional survey included 7248 adults who underwent an annual medical checkup at a single medical institution. API and AVI were measured using cuff oscillometry by trained nurses. We used correlation coefficients, t-tests, and multiple regression analyses to evaluate associations, and calculated intraclass correlation coefficients ICC to examine test-retest reliabilities of these indices.

ResultsMean age was 45.5 years SD = 5.8, and 4083 56.3 % participants were men, while 3165 were women. Mean values of API and AVI were 25.1 SD = 7.0 and 16.6 SD = 5.4, respectively. API was strongly correlated with body mass index BMI, systolic blood pressure sBP, and diastolic blood pressure dBP r > 0.3, p < 0.001. AVI was strongly correlated with age, sBP, and API r > 0.3, p < 0.001. Multiple regression analyses showed that sex, age, BMI, and sBP were independently associated with API. Sex, age, BMI, sBP, fasting plasma glucose FPG, and smoking condition were also independently associated with AVI. As reliabilities of measurements, the ICC of API was 0.74, and the ICC of AVI was 0.80.

ConclusionsThese new noninvasive arterial stiffness indices, which had high test-retest reliabilities, were associated with known risk factors of CVD. Further study is warranted to determine the clinical validity of these indices.

KeywordsArterial stiffness Index Noninvasive Clinical validity Prevalence General population AbbreviationsABIankle brachial pressure index

APIarterial pressure volume index

AVIarterial velocity pulse index

BMIbody mass index

CAVIcardio ankle vascular index

CVDcardiovascular disease

dBPdiastolic blood pressure

FPGfasting plasma glucose

ICCintraclass correlation coefficient

IMTintima-media thickness

PWVpulse wave velocity

sBPsystolic blood pressure

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Autor: Masaki Okamoto - Fumiaki Nakamura - Terunaga Musha - Yasuki Kobayashi


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