Chronic hepatitis infection is associated with extrahepatic cancer development: a nationwide population-based study in TaiwanReportar como inadecuado




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BMC Cancer

, 16:861

Epidemiology, prevention and public health

Abstract

BackgroundHepatitis B virus HBV and hepatitis C virus HCV are the major causes of chronic hepatitis infection CHI. This longitudinal cohort study investigated the association of CHI with hepatic and extrahepatic cancer development in Taiwan.

MethodsPatients with HBV infection and HCV infection were identified from the Taiwan National Health Insurance Research Database. A Cox proportional hazard model was used to calculate hazard ratios HRs and 95 % confidence intervals CIs for determining the association between CHI and cancer development.

ResultsThe patients with HBV infection exhibited an increased risk of colorectal cancer HR: 1.36, 95 % CI: 1.09–1.70, liver cancer HR: 21.47, 95 % CI: 18.0–25.6, gallbladder and extrahepatic bile duct cancer HR: 2.05, 95 % CI: 1.07–3.91, pancreatic cancer HR: 2.61, 95 % CI: 1.47–4.61, kidney cancer HR: 1.72, 95 % CI: 1.10–2.68, ovarian cancer HR: 2.31, 95 % CI: 1.21–4.39, and non-Hodgkin’s lymphoma HR: 2.10, 95 % CI: 1.25–3.52. The patients with HCV infection exhibited an increased risk of liver cancer HR: 25.10, 95 % CI: 20.9–30.2, gallbladder and extrahepatic bile duct cancer HR: 2.60, 95 % CI: 1.42–4.73, ovarian cancer HR: 5.15, 95 % CI: 1.98–13.4, and non-Hodgkin’s lymphoma HR: 2.30, 95 % CI: 1.34–3.96.

ConclusionThe present population-based study revealed that in addition to its association with primary liver cancer, CHI is associated with an increased risk of extrahepatic cancer.

KeywordsHepatitis B virus Hepatitis C virus Cancer risk Taiwan AbbreviationsCHIChronic hepatitis infection

CIConfidence interval

HBsAgHepatitis B surface antigen

HBVHepatitis B virus

HCVHepatitis C virus

HIVHuman immunodeficiency virus

HRHazard ratio

ICD-9-CMInternational classification of diseases, ninth revision, clinical modification

LHID2000Longitudinal health insurance database 2000

NHINational health insurance

NHIRDNational Health insurance research database

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Autor: Abram Bunya Kamiza - Fu-Hsiung Su - Wen-Chang Wang - Fung-Chang Sung - Shih-Ni Chang - Chih-Ching Yeh

Fuente: https://link.springer.com/







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