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Journal of Pregnancy - Volume 2014 2014, Article ID 459192, 3 pages -

Research Article

Department of Obstetrics and Gynecology, Zekai Tahir Burak Women’s Health Care, Training and Research Hospital, Talatpasa Bulvari, 06230 Ankara, Turkey

Department of Obstetrics and Gynecology, Diyarbakır Women’s Health and Children Disease Hospital, Diyarbakır, Turkey

Department of Biochemistry, Zekai Tahir Burak Women’s Health Care, Training and Research Hospital, Talatpasa Bulvari, 06230 Ankara, Turkey

Received 31 July 2014; Revised 15 October 2014; Accepted 23 October 2014; Published 12 November 2014

Academic Editor: Antonio Farina

Copyright © 2014 A. Seval Ozgu-Erdinc et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To evaluate factor XII levels in women with recurrent pregnancy loss RPL in a tertiary referral hospital. Methods. Women who were referred to our hospital for two consecutive abortions or three abortions in between 2007 and 2013 were included in this retrospective observational study. Women were further grouped according to factor XII levels, as <60% and ≥60%. Results. Mean factor XII level was 109.1 ± 35.7% range: 9–200. Ninety-three 7.4% women had factor XII levels < 60%. Mean factor XII level was 44.8 ± 13.1, and levels ranged between 9 and 60 in this group. Only one woman had factor XII level < 10 %. Remaining 1164 92.6% women had factor XII levels ≥ 60%. Mean factor XII level was 114.3 ± 31.7, and levels ranged between 60.3 and 200 in this group, while 1015 72.4% women had factor XII levels within the normal range 60%–150% 100% = 30 μg-mL. Conclusion. Decreased activity of F-XII was diagnosed in 7.4% of women with RPL. We concluded factor XII deficiency that might be a rare but significant factor for RPL, and should be evaluated in women who are investigated for recurrent pregnancy loss.





Autor: A. Seval Ozgu-Erdinc, Cihan Togrul, Ayla Aktulay, Umran Buyukkagnici, Elif Gul Yapar Eyi, and Salim Erkaya

Fuente: https://www.hindawi.com/



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