Study protocol to investigate the effect of a lifestyle intervention on body weight, psychological health status and risk factors associated with disease recurrence in women recovering from breast cancer treatment ISRCTN08045231Reportar como inadecuado




Study protocol to investigate the effect of a lifestyle intervention on body weight, psychological health status and risk factors associated with disease recurrence in women recovering from breast cancer treatment ISRCTN08045231 - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Cancer

, 6:35

First Online: 09 February 2006Received: 31 October 2005Accepted: 09 February 2006DOI: 10.1186-1471-2407-6-35

Cite this article as: Saxton, J.M., Daley, A., Woodroofe, N. et al. BMC Cancer 2006 6: 35. doi:10.1186-1471-2407-6-35

Abstract

BackgroundBreast cancer survivors often encounter physiological and psychological problems related to their diagnosis and treatment that can influence long-term prognosis. The aim of this research is to investigate the effects of a lifestyle intervention on body weight and psychological well-being in women recovering from breast cancer treatment, and to determine the relationship between changes in these variables and biomarkers associated with disease recurrence and survival.

Methods-designFollowing ethical approval, a total of 100 patients will be randomly assigned to a lifestyle intervention incorporating dietary energy restriction in conjunction with aerobic exercise training or normal care control group. Patients randomised to the dietary and exercise intervention will be given individualised healthy eating dietary advice and written information and attend moderate intensity aerobic exercise sessions on three to five days per week for a period of 24 weeks. The aim of this strategy is to induce a steady weight loss of up to 0.5 Kg each week. In addition, the overall quality of the diet will be examined with a view to i reducing the dietary intake of fat to ~25% of the total calories, ii eating at least 5 portions of fruit and vegetables a day, iii increasing the intake of fibre and reducing refined carbohydrates, and iv taking moderate amounts of alcohol. Outcome measures will include body weight and body composition, psychological health status stress and depression, cardiorespiratory fitness and quality of life. In addition, biomarkers associated with disease recurrence, including stress hormones, estrogen status, inflammatory markers and indices of innate and adaptive immune function will be monitored.

DiscussionThis research will provide valuable information on the effectiveness of a practical, easily implemented lifestyle intervention for evoking positive effects on body weight and psychological well-being, two important factors that can influence long-term prognosis in breast cancer survivors. However, the added value of the study is that it will also evaluate the effects of the lifestyle intervention on a range of biomarkers associated with disease recurrence and survival. Considered together, the results should improve our understanding of the potential role that lifestyle-modifiable factors could play in saving or prolonging lives.

Download fulltext PDF



Autor: John M Saxton - Amanda Daley - Nicola Woodroofe - Robert Coleman - Hilary Powers - Nanette Mutrie - Vanessa Siddall - Hele

Fuente: https://link.springer.com/







Documentos relacionados