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BMC Research Notes

, 9:277

Infectious Diseases


BackgroundHuman brucellosis cases are still reported each year in Sweden despite eradication of the disease in animals. Epidemiological investigation has never been conducted to trace back the source of human infection in the country. The purpose of the study was to identify the source of infection for 16 human brucellosis cases that occurred in Sweden, during the period 2008–2012.

ResultsThe isolates were identified as Brucella melitensis and MLVA-16 genotyping revealed 14 different genotypes of East Mediterranean and Africa lineages. We also reported one case of laboratory-acquired brucellosis LAB that was shown to be epidemiological linked to one of the cases in the current study.

ConclusionsBrucella melitensis was the only species diagnosed, confirming its highest zoonotic potential in the genus Brucella, and MLVA-16 results demonstrated that the cases of brucellosis in Sweden herein investigated, are imported and linked to travel in the Middle East and Africa. Due to its zoonotic concerns, any acute febrile illness linked to recent travel within those regions should be investigated for brucellosis and samples should be processed according to biosafety level 3 regulations.

KeywordsBrucellosis Brucella melitensis MLVA AbbreviationsPCRpolymerase chain reaction


VNTRvariable number tandem repeat

MLVAmulti locus VNTRs analysis

BSLbiosafety level

AMOSAbortus Melitensis Ovis Suis

MALDI-TOFmatrix-assisted laser desorption-ionization time-of-flight

UPGMAunweighted pair group method with arithmetic mean

LABlaboratory-acquired brucellosis

Electronic supplementary materialThe online version of this article doi:10.1186-s13104-016-2074-7 contains supplementary material, which is available to authorized users.

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Autor: Giuliano Garofolo - Antonio Fasanella - Elisabetta Di Giannatale - Ilenia Platone - Lorena Sacchini - Tiziana Persiani - Ta


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