Primary hyperparathyroidism in pregnancy treated with cinacalcet: a case report and review of the literatureReport as inadecuate

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Journal of Medical Case Reports

, 10:361

First Online: 20 December 2016Received: 03 March 2016Accepted: 10 October 2016DOI: 10.1186-s13256-016-1093-2

Cite this article as: Vera, L., Oddo, S., Di Iorgi, N. et al. J Med Case Reports 2016 10: 361. doi:10.1186-s13256-016-1093-2


BackgroundThe efficacy and safety of various modes of medical treatment for primary hyperparathyroidism in pregnancy are largely unknown.

Case presentationWe report the case of a 34-year-old white woman with primary hyperparathyroidism symptomatic for nephrolithiasis. Her serum calcium was 3.15 mmol-l and parathyroid hormone was 109.0 ng-L. Neck imaging found no pathological parathyroid tissue. Cinacalcet and cholecalciferol were started. She became pregnant 17 months later. The calcimimetic was stopped. During pregnancy, she was admitted for hydration administered intravenously two to three times per week. In her 24 week of pregnancy, cinacalcet was restarted. In her 32nd week, a cesarean section was carried out as planned.

ConclusionsOnly three cases of primary hyperparathyroidism in women on cinacalcet therapy in pregnancy have been published in the literature. In the present case, hydration was useful in controlling serum calcium. Cinacalcet therapy helped to control serum calcium.

KeywordsCinacalcet Calcimimetic Pregnancy Primary hyperparathyroidism Hypercalcemia Case report AbbreviationsTcTechnetium-99m

CaIonized calcium

CTComputed tomography

FNABFine-needle aspiration biopsy

MENMultiple endocrine neoplasia

NaClSodium chloride

PETPositron emission tomography

PHPTPrimary hyperparathyroidism

PTHParathyroid hormone

PTH-FNABFine-needle washing after aspiration biopsy

PTHrPParathyroid hormone-related protein


S-CaSerum calcium

S-PSerum phosphorous

SPECT-CTSingle-photon emission computed tomography-computed tomography


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Author: Lara Vera - Silvia Oddo - Natascia Di Iorgi - Giorgio Bentivoglio - Massimo Giusti


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