Poor Sleep Quality Is Associated with Dawn Phenomenon and Impaired Circadian Clock Gene Expression in Subjects with Type 2 Diabetes MellitusReport as inadecuate

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International Journal of Endocrinology - Volume 2017 2017, Article ID 4578973, 8 pages - https:-doi.org-10.1155-2017-4578973

Research Article

Department of Endocrinology, Huadong Hospital Affiliated to Fudan University, 221 Yananxi Road, Shanghai 200040, China

Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, China

Correspondence should be addressed to Jiao Sun

Received 3 November 2016; Revised 16 January 2017; Accepted 30 January 2017; Published 2 March 2017

Academic Editor: Darío Acuña-Castroviejo

Copyright © 2017 Yuxin Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aims. We investigated whether poor sleep quality is associated with both dawn phenomenon and impaired circadian clock gene expression in subjects with diabetes. Methods. 81 subjects with diabetes on continuous glucose monitoring were divided into two groups according to the Pittsburgh Sleep Quality Index. The magnitude of dawn phenomenon was quantified by its increment from nocturnal nadir to prebreakfast. Peripheral leucocytes were sampled from 81 subjects with diabetes and 28 normal controls at 09:00. Transcript levels of circadian clock genes BMAL1, PER1, PER2, and PER3 were determined by real-time quantitative polymerase chain reaction. Results. The levels of HbA1c and fasting glucose and the magnitude of dawn phenomenon were significantly higher in the diabetes group with poor sleep quality than that with good sleep quality. Peripheral leucocytes from subjects with poor sleep quality expressed significantly lower transcript levels of BMAL1 and PER1 compared with those with good sleep quality. Poor sleep quality was significantly correlated with magnitude of dawn phenomenon. Multiple linear regression showed that sleep quality and PER1 were significantly independently correlated with dawn phenomenon. Conclusions. Dawn phenomenon is associated with sleep quality. Furthermore, mRNA expression of circadian clock genes is dampened in peripheral leucocytes of subjects with poor sleep quality.

Author: Yuxin Huang, Haidong Wang, Yuan Li, Xiaoming Tao, and Jiao Sun

Source: https://www.hindawi.com/


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