Platelet to lymphocyte ratio as an independent prognostic indicator for prostate cancer patients receiving androgen deprivation therapyReport as inadecuate




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BMC Cancer

, 16:329

Medical and radiation oncology

Abstract

BackgroundPlatelet to Lymphocyte ratio PLR is thought to be associated with a worse outcome in multiple types of cancer. However, the prognostic significance of PLR has not been investigated in the prostate cancer PCa patients receiving hormonal therapy. The objective of this study was to determine the prognostic value of PLR in PCa patients treated with androgen deprivation therapy ADT.

MethodsTwo-hundred-ninety prostate cancer patients who had undergone ADT as first-line therapy were retrospectively analyzed. The blood cell counts were performed at the time of diagnosis. PLR was calculated as the ratio of platelet count to lymphocyte count. Patients were categorized in two groups using a cut-off point of 117.58 as calculated by the receiver-operating curve analysis. Correlations between PLR and clinical characteristics were analyzed. Meanwhile, univariate and multivariate cox regression analyses were performed to determine the associations of PLR with progression-free survival PFS, cancer-specific survival CSS and overall survival OS. Prognostic accuracy was evaluated with the Harrell concordance index.

ResultsThe differences of age, serum prostate-specific antigen PSA level, Gleason score, risk stratification and incidence of metastasis between low PLR group <117.58 and high PLR group ≥117.58 were not statistically significant p > 0.05. Multivariate analyses identified PLR as an independent prognostic factor for PFS hazard ratio HR = 1.581, p = 0.013, CSS HR = 1.768, p = 0.037 and OS HR = 1.650, p = 0.044. The addition of PLR to the final model improved predictive accuracy c-index: 0.747, 0.801 and 0.768 for PFS, CSS and OS compared with the clinicopathological base model c-index: 0.730, 0.778 and 0.746, which included Gleason score and incidence of metastasis.

ConclusionsPLR might play a significant role in the prognosis of PCa patients treated with ADT. Thus, we recommend adding PLR to traditional prognostic model to improve the predictive accuracy.

KeywordsProstate cancer PLR Prognostic factor Survival AbbreviationsADTandrogen deprivation therapy

CIconfidence interval

CSScancer-specific survival

HRhazard ratio

IQRinterquartile range

NLRneutrophil to lymphocyte ratio

OSoverall survival

PCaprostate cancer

PFSprogression-free survival

PLRPlatelet to Lymphocyte ratio

PSAprostate-specific antigen

Electronic supplementary materialThe online version of this article doi:10.1186-s12885-016-2363-5 contains supplementary material, which is available to authorized users.

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Author: Yanqing Wang - Fan Xu - Jiahua Pan - Yinjie Zhu - Xiaoguang Shao - Jianjun Sha - Zezhou Wang - Yong Cai - Qiang Liu - Bai

Source: https://link.springer.com/







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