Intramammary metastatic melanoma of unknown primary origin in a 58-year old patient: a case reportReport as inadecuate

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Journal of Medical Case Reports

, 10:363

First Online: 20 December 2016Received: 09 May 2016Accepted: 24 October 2016DOI: 10.1186-s13256-016-1117-y

Cite this article as: El-Tani, Z., Duc, C., Gluecker, T. et al. J Med Case Reports 2016 10: 363. doi:10.1186-s13256-016-1117-y


BackgroundMalignant melanoma metastasis to the breast is a rare disease.

Case presentationWe present the case of a 58-year-old postmenopausal Caucasian woman with metastatic malignant melanoma of unknown origin of the right breast. She presented with a palpable lump in the inferior quadrant of her right breast. The investigations concluded it was breast metastasis from a malignant melanoma of unknown origin. The treatment consisted of mastectomy and axillary lymph node dissection. Two lymph nodes were positive for tumor cells and one showed extracapsular extension. Our patient did not receive immediate adjuvant therapy. Six weeks after the surgery, our patient presented a relapse in the right axilla a 6 × 4 cm mass with positive internal mammary lymph nodes and a single brain metastasis. This relapse motivated an adjuvant treatment with partial regression of the disease. Currently, our patient presents multiple metastases with poor prognosis.

ConclusionsFrom this experience, we advocate an immediate aggressive handling of melanoma metastasis to the breast.

KeywordsBreast cancer Melanoma Metastatic Diagnosis Therapy AbbreviationsHERHuman epidermal growth factor receptor

FDAFood and Drug Agency

HandEHematoxylin and eosin

ENTEar, Nose and Throat


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Author: Zeina El-Tani - Christophe Duc - Thomas Gluecker - Olivier Cottier


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