Low Intensity Physical Exercise Attenuates Cardiac Remodeling and Myocardial Oxidative Stress and Dysfunction in Diabetic RatsReport as inadecuate

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Journal of Diabetes Research - Volume 2015 2015, Article ID 457848, 10 pages -

Research Article

Department of Internal Medicine, Botucatu Medical School, São Paulo State University UNESP, S-N, Rubião Junior District, 18618 970 Botucatu, SP, Brazil

Sagrado Coração University, Bauru, SP, Brazil

Department of Chemistry and Biochemistry, Institute of Biosciences, São Paulo State University UNESP, Brazil

Received 21 November 2014; Accepted 4 January 2015

Academic Editor: Bagher Larijani

Copyright © 2015 C. Gimenes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We evaluated the effects of a low intensity aerobic exercise protocol on cardiac remodeling and myocardial function in diabetic rats. Wistar rats were assigned into four groups: sedentary control C-Sed, exercised control C-Ex, sedentary diabetes DM-Sed, and exercised diabetes DM-Ex. Diabetes was induced by intraperitoneal injection of streptozotocin. Rats exercised for 9 weeks in treadmill at 11 m-min, 18 min-day. Myocardial function was evaluated in left ventricular LV papillary muscles and oxidative stress in LV tissue. Statistical analysis was given by ANOVA or Kruskal-Wallis. Echocardiogram showed diabetic groups with higher LV diastolic diameter-to-body weight ratio and lower posterior wall shortening velocity than controls. Left atrium diameter was lower in DM-Ex than DM-Sed C-Sed: ; C-Ex: ; DM-Sed: ; DM-Ex:  mm; DM-Sed vs C-Sed and DM-Ex. Papillary muscle function was depressed in DM-Sed compared to C-Sed. Exercise attenuated this change in DM-Ex. Lipid hydroperoxide concentration was higher in DM-Sed than C-Sed and DM-Ex. Catalase and superoxide dismutase activities were lower in diabetics than controls and higher in DM-Ex than DM-Sed. Glutathione peroxidase activity was lower in DM-Sed than C-Sed and DM-Ex. Conclusion. Low intensity exercise attenuates left atrium dilation and myocardial oxidative stress and dysfunction in type 1 diabetic rats.

Author: C. Gimenes, R. Gimenes, C. M. Rosa, N. P. Xavier, D. H. S. Campos, A. A. H. Fernandes, M. D. M. Cezar, G. N. Guirado, A. C

Source: https://www.hindawi.com/


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