Importance of hereditary and selected environmental risk factors in the etiology of inflammatory breast cancer: a case-comparison studyReport as inadecuate




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BMC Cancer

, 16:334

Epidemiology, prevention and public health

Abstract

BackgroundTo assess the importance of heredity in the etiology of inflammatory breast cancer IBC, we compared IBC patients to several carefully chosen comparison groups with respect to the prevalence of first-degree family history of breast cancer.

MethodsIBC cases n = 141 were compared to non-inflammatory breast cancer cases n = 178 ascertained through George Washington University GWU with respect to the prevalence of first-degree family history of breast cancer and selected environmental-lifestyle risk factors for breast cancer. Similar comparisons were conducted with subjects from three case–control studies: breast cancer cases n = 1145 and unaffected controls n = 1142 from the Cancer Genetic Markers of Susceptibility CGEMS study, breast cancer cases n = 465 and controls n = 9317 from the Women’s Health Initiative WHI study, and ovarian cancer cases n = 260 and controls n = 331 from a study by University of Toronto UT.

ResultsThe frequency of first-degree breast cancer family history among IBC cases was 17.0 % compared to 24.4 % for GWU breast cancer cases, 23.9 % and 17.9 % for CGEMS breast cancer cases and controls, respectively, 16.9 % and 12.6 % for WHI breast cancer cases and controls, respectively, and 24.2 % and 11.2 % for UT ovarian cancer cases and controls, respectively.

IBC cases had a significantly lower prevalence of parous women than WHI breast cancer cases OR = 0.46, 95 % CI:0.27–0.81 and controls OR = 0.31, 95 % CI:0.20–0.49. Oral contraceptive use was significantly higher among IBC cases compared to WHI breast cancer cases OR = 7.77, 95 % CI:4.82–12.59 and controls OR = 8.14, 95 % CI:5.28–12.61. IBC cases had a significantly higher frequency of regular alcohol consumption ≥1 drink per day compared to WHI controls OR = 1.84, 95 % CI:1.20–2.82 and UT controls OR = 1.86, 95 % CI:1.07–3.22 and higher statistically non-significant prevalence 21.3 % compared to breast cancer cases from GWU 18.2 % and WHI 15.2 %.

ConclusionsThe prevalence of first-degree breast cancer family history among IBC cases was lower compared to breast and ovarian cancer cases but higher than unaffected individuals. Our multiple-case inflammatory and non-inflammatory breast cancer families may reflect aggregation of common genetic and-or environmental factors predisposing to both types of breast cancer. Our findings that oral contraceptive use and regular alcohol consumption may be associated with IBC warrant further investigations.

KeywordsInflammatory breast cancer IBC Heredity Case-comparison study Family history of breast cancer Breast cancer risk factors Multiplex IBC families  Download fulltext PDF



Author: Roxana Moslehi - Elizabeth Freedman - Nur Zeinomar - Carmela Veneroso - Paul H. Levine

Source: https://link.springer.com/







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