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Gastroenterology Research and PracticeVolume 2012 2012, Article ID 457831, 6 pages

Research Article

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, NTNU, 7006 Trondheim, Norway

Department of Laboratory Medicine, Children-s and Women-s Health, Faculty of Medicine, NTNU, 7006 Trondheim, Norway

Department of Pathology and Medical Genetics, St. Olavs Hospital, 7006 Trondheim, Norway

Department of Gastroenterology and Hepatology, St. Olavs Hospital, 7006 Trondheim, Norway

Received 4 October 2011; Accepted 13 December 2011

Academic Editor: Y. Yamaoka

Copyright © 2012 Karin E. Bakkelund et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. Gastric adenocarcinomas localized to the cardia are increasing. Enterochromaffin-like ECL cells play a role in gastric carcinogenesis in hypergastrinemia, and the use of proton pump inhibitors PPI leading to hypergastrinemia has increased considerably during the last decades. We have examined cardia cancers for neuroendocrine and ECL cell differentiation. Methods. Thirty-two cardia cancers were examined by immunohistochemical labelling of chromogranin A CgA, synaptophysin, serotonin, and histidine decarboxylase HDC. Information about PPI use was collected from the patient records. Results. In 15 of 32 tumours, there were positive signs for one or several neuroendocrine markers. Five cases were CgA and serotonin positive; three of these carcinomas were also positive for HDC. Three patients were long-term users of PPI, and two of these were immunoreactive for neuroendocrine markers. Conclusions. A high proportion of cardia cancers expressed neuroendocrine markers, but only few patients with cardia cancers were using PPI.

Author: Karin E. Bakkelund, Ivar S. Nordrum, Reidar Fossmark, and Helge L. Waldum



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