Economic evidence for the prevention and treatment of atopic eczema: a protocol for a systematic reviewReport as inadecuate

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Systematic Reviews

, 5:90

First Online: 27 May 2016Received: 12 January 2016Accepted: 10 May 2016DOI: 10.1186-s13643-016-0262-0

Cite this article as: Sach, T.H., McManus, E., Mcmonagle, C. et al. Syst Rev 2016 5: 90. doi:10.1186-s13643-016-0262-0


BackgroundEczema, synonymous with atopic eczema or atopic dermatitis, is a chronic skin disease that has a similar impact on health-related quality of life as other chronic diseases. The proposed research aims to provide a comprehensive systematic assessment of the economic evidence base available to inform economic modelling and decision making on interventions to prevent and treat eczema at any stage of the life course. Whilst the Global Resource of Eczema Trials GREAT database collects together the effectiveness evidence for eczema, there is currently no such systematic resource on the economics of eczema. It is important to gain an overview of the current state of the art of economic methods in the field of eczema in order to strengthen the economic evidence base further.

Methods-designThe proposed study is a systematic review of the economic evidence surrounding interventions for the prevention and treatment of eczema. Relevant search terms will be used to search MEDLINE, EMBASE, Database of

Abstracts of Reviews of Effects, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, National Health Service NHS Economic Evaluation Database, Health Technology Assessment, Cumulative Index to Nursing and Allied Health Literature, EconLit, Scopus, Cost-Effectiveness Analysis Registry and Web of Science in order to identify relevant evidence. To be eligible for inclusion studies will be primary empirical studies evaluating the cost, utility or full economic evaluation of interventions for preventing or treating eczema. Two reviewers will independently assess studies for eligibility and perform data abstraction. Evidence tables will be produced presenting details of study characteristics, costing methods, outcome methods and quality assessment. The methodological quality of studies will be assessed using accepted checklists.

DiscussionThe systematic review is being undertaken to identify the type of economic evidence available, summarise the results of the available economic evidence and critically appraise the quality of economic evidence currently available to inform future economic modelling and resource allocation decisions about interventions to prevent or treat eczema. We aim to use the review to offer guidance about how to gather economic evidence in studies of eczema and-or what further research is necessary in order to inform this.

Systematic review registrationPROSPERO CRD42015024633

KeywordsEczema Economics Costs Health-related quality of life Cost effectiveness AbbreviationsCHEERSConsolidated Health Economic Evaluation Reporting Standards

GPGeneral Practitioner

GREATGlobal Resource for Eczema Trials

HQoLHealth-Related Quality of Life

ICERIncremental Cost Effectiveness Ratio

JLAJames Lind Alliance

NANot Applicable

NHSNational Health Service

NICENational Institute of Health and Care Excellence

PSPPriority Setting Partnership

QALYsQuality Adjusted Life Years

UKUnited Kingdom

Electronic supplementary materialThe online version of this article doi:10.1186-s13643-016-0262-0 contains supplementary material, which is available to authorized users.

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Author: Tracey Helen Sach - Emma McManus - Christopher Mcmonagle - Nick Levell


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