Involvement of Cell Proliferation Induced by Dual Intracellular Signaling of HB-EGF in the Development of Colitis-Associated Cancer during Ulcerative ColitisReport as inadecuate




Involvement of Cell Proliferation Induced by Dual Intracellular Signaling of HB-EGF in the Development of Colitis-Associated Cancer during Ulcerative Colitis - Download this document for free, or read online. Document in PDF available to download.

UlcersVolume 2011 2011, Article ID 457637, 6 pages

Review ArticleDepartment of Gastroenterology and Metabolism, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho, Nagoya, Aichi 467-8601, Japan

Received 31 July 2010; Accepted 27 September 2010

Academic Editor: Takafumi Ando

Copyright © 2011 Satoshi Tanida et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In ulcerative colitis UC, the duration and severity of inflammation are responsible for the development of colorectal cancer. Reactive oxygen species ROS, reactive nitric metabolites RNMs and interleukin IL-8, released by epithelial and immune cells, are involved in the pathogenesis of colitis-associated cancer. Nitric oxide and peroxynitrite activate epidermal growth factor receptor EGFR, and therapeutic agents targeted towards EGFR are currently used to treat advanced colorectal cancer. IL-8 a G-protein coupled receptor GPCR agonist, which is involved in neutrophil recruitment and activation in persistent active colitis, also promotes cleavage of the proheparin-binding epidermal growth factor-like growth factor proHB-EGF through a disintegrin and metalloproteinase ADAM. The cleaved HB-EGF and C-terminal fragments intracellular CTF regulate proliferation via EGFR activation and nuclear export of promyelocytic leukemia zinc finger, transcription repressor, respectively. Here, we focus on the mechanisms by which RNM- and IL-8-induced EGF signaling regulate cell proliferation during the development of colitis-associated cancer.





Author: Satoshi Tanida, Tsutomu Mizoshita, Takashi Mizushima, Takaya Shimura, Takeshi Kamiya, Hiromi Kataoka, and Takashi Joh

Source: https://www.hindawi.com/



DOWNLOAD PDF




Related documents