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Journal of Endocrinological Investigation

, Volume 40, Issue 1, pp 1–8

First Online: 29 July 2016Received: 14 June 2016Accepted: 21 July 2016DOI: 10.1007-s40618-016-0523-8

Cite this article as: Polak, K., Czyzyk, A., Simoncini, T. et al. J Endocrinol Invest 2017 40: 1. doi:10.1007-s40618-016-0523-8


Polycystic ovary syndrome PCOS is the most common endocrine-metabolic disorder in women of reproductive age. The diagnostic criteria include two out of three features: hyperandrogenism, polycystic ovaries on ultrasound and menstrual irregularities Rotterdam Criteria 2003. PCOS patients are more vulnerable to develop diabetes, cardiovascular diseases and metabolic syndrome. Insulin resistance IR is prevalent in women with PCOS independently of obesity and is critically involved in reproductive and metabolic complications of the syndrome. Several tests have been developed to measure IR, some very reliable but complex like the hyperinsulinemic euglycemic glucose clamp and others less precise but easier and less invasive like HOMA-IR. New markers are needed to reach a more reliable assessment of insulin resistance. To date, several surrogate markers have been proposed in the literature to facilitate and improve the determination of IR. Many new proteins are strongly involved with PCOS physiopathology and IR, such as some adipocytokines adiponectin, visfatin, vaspin and apelin, copeptin, irisin, PAI-1 and zonulin. Many other proteins have been proposed as potential new markers of IR in PCOS, such as resistin, leptin, RBP4, kisspetin and ghrelin, but their role is still controversial. In this review, we provide a short characterization of these new markers, recently studied as indicators of metabolic state.

KeywordsPolycystic ovary syndrome Insulin resistance Markers Adipocytokines  Download fulltext PDF

Author: K. Polak - A. Czyzyk - T. Simoncini - B. Meczekalski


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