Reducing Microvascular Dysfunction in Revascularized Patients with ST-Elevation Myocardial Infarction by Off-Target Properties of Ticagrelor versus Prasugrel. Rationale and Design of the REDUCE-MVI StudyReport as inadecuate




Reducing Microvascular Dysfunction in Revascularized Patients with ST-Elevation Myocardial Infarction by Off-Target Properties of Ticagrelor versus Prasugrel. Rationale and Design of the REDUCE-MVI Study - Download this document for free, or read online. Document in PDF available to download.

Journal of Cardiovascular Translational Research

, Volume 9, Issue 3, pp 249–256

First Online: 21 April 2016Received: 01 March 2016Accepted: 05 April 2016DOI: 10.1007-s12265-016-9691-3

Cite this article as: Janssens, G.N., van Leeuwen, M.A.H., van der Hoeven, N.W. et al. J. of Cardiovasc. Trans. Res. 2016 9: 249. doi:10.1007-s12265-016-9691-3

Abstract

Microvascular injury is present in a large proportion of patients with ST-elevation myocardial infarction STEMI despite successful revascularization. Ticagrelor potentially mitigates this process by exerting additional adenosine-mediated effects. This study aims to determine whether ticagrelor is associated with a better microvascular function compared to prasugrel as maintenance therapy after STEMI. A total of 110 patients presenting with STEMI and additional intermediate stenosis in another coronary artery will be studied after successful percutaneous coronary intervention PCI of the infarct-related artery. Patients will be randomized to treatment with ticagrelor or prasugrel for 1 year. FFR-guided PCI of the non-infarct-related artery will be performed at 1 month. Microvascular function will be assessed by measurement of the index of microcirculatory resistance IMR in the infarct-related artery and non-infarct-related artery, immediately after primary PCI and after 1 month. The REDUCE-MVI study will establish whether ticagrelor as a maintenance therapy may improve microvascular function in patients after revascularized STEMI.

KeywordsTicagrelor Prasugrel Microvascular injury ST-elevation myocardial infarction Adenosine AbbreviationsAEAdverse event

CMRCardiovascular magnetic resonance

DESDrug-eluting stent

FFRFractional flow reserve

IMRIndex of microcirculatory resistance

MRIMagnetic resonance imaging

MVIMicrovascular injury

OCTOptical coherence tomography

PCIPercutaneous coronary intervention

RCARight coronary artery

RHIReactive hyperemia index

SAESerious adverse event

STEMIST-elevation myocardial infarction

Associate Editor Emanuele Barbato oversaw the review of this article

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Author: Gladys N. Janssens - Maarten A. H. van Leeuwen - Nina W. van der Hoeven - Guus A. de Waard - Robin Nijveldt - Roberto

Source: https://link.springer.com/







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