Deciphering the gene expression profile of peroxisome proliferator-activated receptor signaling pathway in the left atria of patients with mitral regurgitationReport as inadecuate




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Journal of Translational Medicine

, 14:157

Cardiovascular, Metabolic andLipoprotein Translation

Abstract

BackgroundDifferentially expressed genes in the left atria of mitral regurgitation MR pigs have been linked to peroxisome proliferator-activated receptor PPAR signaling pathway in the KEGG pathway. However, specific genes of the PPAR signaling pathway in the left atria of MR patients have never been explored.

MethodsThis study enrolled 15 MR patients with heart failure, 7 patients with aortic valve disease and heart failure, and 6 normal controls. We used PCR assay 84 genes for PPAR pathway and quantitative RT-PCR to study specific genes of the PPAR pathway in the left atria.

ResultsGene expression profiling analysis through PCR assay identified 23 genes to be differentially expressed in the left atria of MR patients compared to normal controls. The expressions of APOA1, ACADM, FABP3, ETFDH, ECH1, CPT1B, CPT2, SLC27A6, ACAA2, SMARCD3, SORBS1, EHHADH, SLC27A1, PPARGC1B, PPARA and CPT1A were significantly up-regulated, whereas the expression of PLTP was significantly down-regulated in the MR patients compared to normal controls. The expressions of HMGCS2, ACADM, FABP3, MLYCD, ECH1, ACAA2, EHHADH, CPT1A and PLTP were significantly up-regulated in the MR patients compared to patients with aortic valve disease. Notably, only ACADM, FABP3, ECH1, ACAA2, EHHADH, CPT1A and PLTP of the PPAR pathway were significantly differentially expressed in the MR patients compared to patients with aortic valve disease and normal controls.

ConclusionsDifferentially expressed genes of the PPAR pathway have been identified in the left atria of MR patients compared with patients with aortic valve disease and normal controls.

KeywordsAtrium Genes Mitral regurgitation  Download fulltext PDF



Author: Mien-Cheng Chen - Jen-Ping Chang - Yu-Sheng Lin - Kuo-Li Pan - Wan-Chun Ho - Wen-Hao Liu - Tzu-Hao Chang - Yao-Kuang Huang

Source: https://link.springer.com/







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