Organizing pneumonia as the first manifestation of anti-synthetase syndromeReport as inadecuate

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BMC Research Notes

, 9:290

Musculoskeletal Disorders


BackgroundAnti-synthetase syndrome associated interstitial lung disease can occur either simultaneously, before, or after the development of polymyositis-dermatomyositis. Histology of interstitial lung disease can be nonspecific interstitial pneumonia, usual interstitial pneumonia, diffuse alveolar damage, organizing pneumonia. Organizing pneumonia associated anti-synthetase syndrome is a rare finding especially as the first manifestation.

Case presentationWe report a 41 year old male patient who presented with organizing pneumonia and 2 years following the onset, developed polymyositis with anti-JO-1 antibody positivity.

ConclusionIt is important to screen patients with organizing pneumonia for anti-synthetase syndrome which can be manifested later.

KeywordsAnti-synthetase syndrome Interstitial lung disease Polymyositis Organizing pneumonia Anti-JO-1 antibody AbbreviationsPMpolymyositis


ILDinterstitial lung disease

BOOPbronchiolitis obliterance organizing pneumonia

OPorganizing pneumonia

NSIPnonspecific interstitial pneumonia

DADdiffuse alveolar damage

UIPusual interstitial pneumonia

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Author: S. M. Thanuja Nilushi Priyangika - W. G. S. G. karunarathna - Isurujith Liyanage - Methsala Gunawardana - Sumeda Udumal


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