Long-term outcomes in radically treated synchronous vs. metachronous oligometastatic non-small-cell lung cancerReport as inadecuate




Long-term outcomes in radically treated synchronous vs. metachronous oligometastatic non-small-cell lung cancer - Download this document for free, or read online. Document in PDF available to download.

BMC Cancer

, 16:348

Medical and radiation oncology

Abstract

BackgroundRadical treatment for oligometastatic non-small-cell lung cancer NSCLC has a curative potential for selected patients. The present retrospective study was designed to examine the relevance of synchronous vs. metachronous manifestations as a potential prognostic factor when ablative treatments are performed in oligometastatic disease.

MethodsSeventy-five patients with radically treated oligometastatic NSCLC were identified, of whom 39 presented with synchronous and 36 with metachronous metastatic manifestations. For patients with synchronous metastases, an additional therapy of the thoracic locoregional disease with a curative intent either surgery or radiochemotherapy was required. All patients with metachronous metastases had a documented remission of the primary tumor. Ablative treatment of the complete extent of oligometastatic disease consisted as a minimum requirement of either complete surgical resection or definitive ablative stereotactic radiotherapy. A comparative survival analysis of two groups of patients with oligometastatic NSCLC synchronous vs. metachronous and a complementary analysis of prognostic factors for the whole group of patients by means of Cox regression analysis was performed. Endpoints were median overall and progression-free survival OS, PFS, respectively.

ResultsOf the 75 patients, 57 presented with a solitary metastasis, in only 7 patients metastastatic lesions were present in ≥2 organs and 66 patients had a Karnofsky performance score KPS of 80 % or 90 %. The median follow-up was 54.0 months 95 % CI 28–81, the median OS 21.8 months 16.1–27.6 and the median PFS 13.7 months 9.7–17.6. In univariable Cox regression analysis, no single clinical factor was significantly associated with OS. For PFS both ‘metastatic involvement of ≥2 organs vs. 1 organ’ hazard ratio HR 0.43, 0.23–0.83, p = 0.012 and a ‘KPS of 90 % vs. 70–80 %’ HR 4.32, 1.73–10.89, p = 0.02 were significant prognostic factors as calculated by multivariable analysis. Comparing the cohorts with synchronous n = 39 vs. metachronous oligometastases n = 36, no differences in median OS and PFS were found. Both cohorts were well-balanced except for the KPS, which was significantly superior in patients with synchronous oligometastases.

ConclusionsRadical treatment of oligometastatic NSCLC was associated with acceptable long-term survival rates in patients with good KPS and it was equally effective for synchronous and metachronous manifestations.

KeywordsNSCLC Oligometastatic disease Radical treatment SBRT Electronic supplementary materialThe online version of this article doi:10.1186-s12885-016-2379-x contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Jochen Fleckenstein - Alev Petroff - Hans-Joachim Schäfers - Thomas Wehler - Jakob Schöpe - Christian Rübe

Source: https://link.springer.com/







Related documents