Acquired factor XII deficiency in a woman with recurrent pregnancy loss: working on a differential diagnosis in a single caseReport as inadecuate




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Journal of Translational Medicine

, 3:43

First Online: 02 December 2005Received: 05 October 2005Accepted: 02 December 2005DOI: 10.1186-1479-5876-3-43

Cite this article as: D-Uva, M., Strina, I., Mollo, A. et al. J Transl Med 2005 3: 43. doi:10.1186-1479-5876-3-43

Abstract

BackgroundAntiphospholipid syndrome APS has been often associated to RPL since 1980 and some reports in the Literature rarely described antibodies to factor XII in patients with APS.

Case historyWe report the case history of 34-year-old caucasian women with recurrent fetal loss and persistent prolonged activated partial thromboplastin time. Haemostatic tests revealed persistent light decrease of clotting factor XII with normal values of IgG and IgM anticardiolipin antibodies and transient positivity for lupus anticoagulant LA. Few reports in the Literature described antibodies to factor XII in patient with antiphospholipid syndrome APS and transient LA. So, once other causes of RPL were excluded, the patient was diagnosed an unusual form of APS associated to antibodies to factor XII, reduced factor XII plasma levels, transient LA and prolonged activated partial thromboplastin time.

DiscussionWe suggest to consider also antibodies directed to clotting factors e.g. factor XII in our case as second step of thrombophilia screening in RPL, in particular if a persistent prolonged aPTT is present without an apparent cause.

Electronic supplementary materialThe online version of this article doi:10.1186-1479-5876-3-43 contains supplementary material, which is available to authorized users.

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Author: Maristella D-Uva - Ida Strina - Antonio Mollo - Antonio Ranieri - Giuseppe De Placido - Pierpaolo Di Micco

Source: https://link.springer.com/







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