Long range physical cell-to-cell signalling via mitochondria inside membrane nanotubes: a hypothesisReport as inadecuate




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Theoretical Biology and Medical Modelling

, 13:16

Biophysical Models of Cell Behavior

Abstract

Coordinated interaction of single cells by cell-to-cell communication signalling enables complex behaviour necessary for the functioning of multicellular organisms. A quite newly discovered cell-to-cell signalling mechanism relies on nanotubular cell-co-cell connections, termed -membrane nanotubes- MNTs. The present paper presents the hypothesis that mitochondria inside MNTs can form a connected structure mitochondrial network which enables the exchange of energy and signals between cells. It is proposed that two modes of energy and signal transmission may occur: electrical-electrochemical and electromagnetic optical. Experimental work supporting the hypothesis is reviewed, and suggestions for future research regarding the discussed topic are given.

KeywordsMembrane nanotubes Mitochondrial networks Mitochondrial reticulum Filamentous mitochondria Mitochondrial membrane potential Ultra-weak photon emission Cell-to-cell signalling Long-range signalling  Download fulltext PDF



Author: Felix Scholkmann

Source: https://link.springer.com/







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