Increased risk of cancer among relatives of patients with lung cancer in ChinaReport as inadecuate

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BMC Cancer

, 5:146

First Online: 11 November 2005Received: 17 July 2005Accepted: 11 November 2005DOI: 10.1186-1471-2407-5-146

Cite this article as: Jin, Y., Xu, Y., Xu, M. et al. BMC Cancer 2005 5: 146. doi:10.1186-1471-2407-5-146


BackgroundGenetic factors were considered as one of the risk factors for lung cancer or other cancers. The aim of this work was to determine whether a genetic predisposition accounts for such familial aggregation of cancer among relatives of lung cancer probands.

MethodsA case-control study was conducted in 800 case families identified by lung cancer patients probands, and in 800 control families identified by the probands-spouses. The data were analysed with logistic regression analysis model.

ResultsThe data revealed a significantly greater overall risk of cancer OR = 1.82, P < 0.01 in the proband group. The relatives of lung cancer probands maintained an increased risk of non-lung cancer P < 0.05 after adjusting for confounder factors. The crude odds ratio of a proband family having one family member with cancer was 1.67 compared with control families. Proband families were 2.56 times more likely to have two other family members with cancer. For three cancers and four or more cancers, the risk increased to 3.50 and 5.91, respectively. The most striking differences in cancer prevalence between proband and control families were noted for cancer risk among female relatives. The strongest effects were for not only lung cancer in any female relatives OR 2.17, 95%CI 1.60–3.64 and mothers OR 2.78, 95%CI 1.23–5.12 and sisters OR 2.03, 95%CI 1.26–3.97, but also non-lung cancer in females and mothers OR 2.00, 95%CI 1.26–3.01, and OR 2.34, 95%CI 1.28–4.40, respectively.

ConclusionThese data support the hypothesis of a genetic susceptibility to cancer in families with lung cancer, and the female genetic susceptibility to cancer might be greater than male.

AbbreviationsICDinternational classification of diseases

COPDchronic obstructive pulmonary disease

ORodds ratio

CIconfidence interval

GSTglutathione S-transferase

CYPcytochrome P450

MPOmyeloperoxidase and NQO1

NADPHquinone oxidoreductase

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Author: Yongtang Jin - Yingchun Xu - Ming Xu - Saoli Xue


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